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The Scientific World Journal
Volume 2014, Article ID 709736, 9 pages
Review Article

Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer

1Second Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieion University Hospital, 76 Vas. Sofias Avenue, 11527 Athens, Greece
2Department of Gynecology and Obstetrics, The Johns Hopkins Hospital School of Medicine, Baltimore, MD 21287, USA

Received 30 August 2013; Accepted 9 October 2013; Published 12 January 2014

Academic Editors: D. H. Dinh, E. K. Han, D. G. Mutch, and E. O. Pettersen

Copyright © 2014 Athanasia Pavlidou and Nikos F. Vlahos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers. Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer. This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented.