Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 721547, 8 pages
http://dx.doi.org/10.1155/2014/721547
Research Article

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

1Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, Iran
2Afzal Research Center, Kerman, Iran

Received 4 July 2014; Revised 8 November 2014; Accepted 26 November 2014; Published 29 December 2014

Academic Editor: Rosanna Maccari

Copyright © 2014 Nasser Zangiabadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Zangiabadi, M. Asadi-Shekaari, V. Sheibani et al., “Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis,” Oxidative Medicine and Cellular Longevity, vol. 2011, Article ID 976948, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Gallieni, A. Aiello, B. Tucci et al., “The burden of hypertension and kidney disease in northeast India: the institute for indian mother and child noncommunicable diseases project,” The Scientific World Journal, vol. 2014, Article ID 320869, 6 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Belchetz and P. J. Hammond, Mosby's Color Atlas and Text of Diabetes and Endocrinology, Mosby, Edinburgh, UK, 2003.
  4. N. N. Houreld, “Shedding light on a new treatment for diabetic wound healing: a review on phototherapy,” The Scientific World Journal, vol. 2014, Article ID 398412, 13 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. R. J. Lederman, “Bradley's neurology in clinical practice,” JAMA, vol. 308, no. 16, p. 1694, 2012. View at Google Scholar
  6. R. J. Tanenberg, “Diabetic peripheral neuropathy: painful or painless,” Hospital Physician, vol. 45, no. 7, pp. 1–8, 2009. View at Google Scholar
  7. S. Skalska, Z. Kyselova, A. Gajdosikova, C. Karasu, M. Stefek, and S. Stolc, “Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E,” General Physiology and Biophysics, vol. 27, no. 2, pp. 106–114, 2008. View at Google Scholar · View at Scopus
  8. N. M. Afifi, “Neuroprotective effect of melatonin in a rat model of streptozotocin-induced diabetic neuropathy: light and electron microscopic study,” Egyptian Journal of Histology, vol. 36, no. 2, pp. 321–335, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Zangiabadi, M. N. Ahrari, and N. Nakhaee, “The effect of omega-3 fatty acids on nerve conduction velocity (NCV) and F-wave latency in patients with diabetic polyneuropathy,” American Journal of Pharmacology and Toxicology, vol. 2, no. 1, pp. 1–3, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Nicolucci, F. Carinci, D. Cavaliere et al., “A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy,” Diabetic Medicine, vol. 13, no. 12, pp. 1017–1026, 1996. View at Google Scholar
  11. N. Zangiabadi, K. Shafiee, K. H. Alavi, A. R. Assadi, and M. Damavandi, “Atorvastatin treatment improves diabetic polyneuropathy electrophysiological changes in non-insulin dependent diabetic patients: a double blind, randomized clinical trial,” Minerva Endocrinologica, vol. 37, no. 2, pp. 195–200, 2012. View at Google Scholar · View at Scopus
  12. A. Consoli, “Chronic venous insufficiency: an open trial of FLEBS CREMA,” Minerva Cardioangiologica, vol. 51, no. 4, pp. 411–416, 2003. View at Google Scholar · View at Scopus
  13. A. A. Podkolzin, V. I. Dontsov, I. A. Sychev, G. I. Kobeleva, and O. N. Kharchenko, “Immunocorrecting, antianemia, and adaptogenic effects of polysaccharides from Melilotus officinalis,” Biulleten' Eksperimental'noi Biologii i Meditsiny, vol. 121, no. 6, pp. 661–663, 1996. View at Google Scholar · View at Scopus
  14. R. Heshmat, K. Mohammad, M. R. Mohajeri Tehrani et al., “Assessment of maximum tolerated dose of a new herbal drug, Semelil (ANGIPARS) in patients with diabetic foot ulcer: a Phase I clinical trial,” Daru, vol. 16, supplement 1, pp. 25–30, 2008. View at Google Scholar · View at Scopus
  15. K. Shamimi Nouri, R. Karimian, E. Nasli et al., “Topical application of Semelil (ANGIPARS) in treatment of pressure ulcers: a randomized clinical trial,” Daru, vol. 16, no. 1, pp. 54–57, 2008. View at Google Scholar · View at Scopus
  16. G. Vettorello, G. Cerreta, A. Derwish et al., “Contribution of an association of α and β benzopyrones, flavonoids and natural terpenes in the treatment of II stage lymphedema of the lover limbs,” Minerva Cardioangiologica, vol. 44, no. 9, pp. 447–455, 1996. View at Google Scholar · View at Scopus
  17. T. Hirakawa, M. Okawa, J. Kinjo, and T. Nohara, “A new oleanene glucuronide obtained from the aerial parts of Melilotus officinalis,” Chemical and Pharmaceutical Bulletin, vol. 48, no. 2, pp. 286–287, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. U. A. Shinde and R. K. Goyal, “Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats,” Journal of Cellular and Molecular Medicine, vol. 7, no. 3, pp. 322–329, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Liepinsh, R. Vilskersts, L. Zvejniece et al., “Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats,” British Journal of Pharmacology, vol. 157, no. 8, pp. 1549–1556, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Shabani, M. Nazeri, S. Parsania et al., “Walnut consumption protects rats against cisplatin-induced neurotoxicity,” NeuroToxicology, vol. 33, no. 5, pp. 1314–1321, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Shabani, N. Hosseinmardi, M. Haghani, V. Shaibani, and M. Janahmadi, “Maternal exposure to the CB1 cannabinoid agonist WIN 55212-2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring,” Neuroscience, vol. 172, pp. 139–152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Shabani, M. H. Larizadeh, S. Parsania, V. Hajali, and A. Shojaei, “Evaluation of destructive effects of exposure to cisplatin during developmental stage: no profound evidence for sex differences in impaired motor and memory performance,” International Journal of Neuroscience, vol. 122, no. 8, pp. 439–448, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. C.-Q. Xia, R. Peng, Y. Qiu, M. Annamalai, D. Gordon, and M. J. Clare-Salzler, “Transfusion of apoptotic β-cells induces immune tolerance to β-cell antigens and prevents type 1 diabetes in NOD mice,” Diabetes, vol. 56, no. 8, pp. 2116–2123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. A. P. Mizisin, G. D. Shelton, S. Wagner, C. Rusbridge, and H. C. Powell, “Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy,” Acta Neuropathologica, vol. 95, no. 2, pp. 171–174, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Shimada, T. Miki, I. Kyogoku et al., “Effects of the aldose reductase inhibitor on diabetic polyneuropathy: the efficacy of F wave measurement,” Brain and Nerve, vol. 50, no. 9, pp. 817–820, 1998. View at Google Scholar · View at Scopus
  26. A. H. Ropper, Adams and Victor's Principles of Neurology, McGraw-Hill Medical Pubication Division, New York, NY, USA, 2005.
  27. K. Sugimoto and S. Yagihashi, “Peripheral nerve pathology in rats with streptozotocin-induced insulinoma,” Acta Neuropathologica, vol. 91, no. 6, pp. 616–623, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Forbes, M. T. Coughlan, and M. E. Cooper, “Oxidative stress as a major culprit in kidney disease in diabetes,” Diabetes, vol. 57, no. 6, pp. 1446–1454, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. B. Larijani, R. Heshmat, A. Bahrami et al., “Effects of intravenous Semelil (ANGIPARSTM) on diabetic foot ulcers healing: a multicenter clinical trial,” DARU Journal of Pharmaceutical Sciences, vol. 16, supplement 1, pp. 35–40, 2008. View at Google Scholar
  31. M. Asadi-Shekaari, H. E. Vaghefi, A. Talakoub, and H. R. K. Khorshid, “Effects of Semelil (ANGIPARS) on focal cerebral ischemia in male rats,” DARU, vol. 18, no. 4, pp. 265–269, 2010. View at Google Scholar · View at Scopus
  32. P. Sheehan, P. Jones, A. Caselli, J. M. Giurini, and A. Veves, “Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial,” Diabetes Care, vol. 26, no. 6, pp. 1879–1882, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. W. H. Goodson III and T. K. Hunt, “Studies of wound healing in experimental diabetes mellitus,” Journal of Surgical Research, vol. 22, no. 3, pp. 221–227, 1977. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Mayfield, G. Reiber, L. Sanders, D. Janisse, and L. Pogach, “Preventive foot care in people with diabetes,” Diabetes Care, vol. 26, supplement 1, pp. S78–S79, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. R. L. F. Cecil and L. Goldman, CECIL Textbook of Medicine, Saunders, 1997.
  36. M. Kihara, J. D. Schmelzer, Y. Kihara, I. L. Smithson, and P. A. Low, “Efficacy of limb cooling on the salvage of peripheral nerve from ischemic fiber degeneration,” Muscle & Nerve, vol. 19, no. 2, pp. 203–209, 1996. View at Google Scholar