Research Article

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

Table 2

The effect of Angipars on histomorphometric parameters of rat sciatic nerve.

GroupsMMFD (μm)AD (μm)MSD (μm)

Control66.13 ± 0.886.91 ± 1.455.35 ± 0.34
Vehicle69.45 ± 0.45****4.59 ± 0.76**4.98 ± 0.71
Angipars 5 612.59 ± 1.05****#6.84 ± 0.99##5.65 ± 0.92
Angipars 10 611.65 ± 1.22****#5.75 ± 1.205.91 ± 0.82
Angipars 20 611.81 ± 0.73****#6.00 ± 0.775.83 ± 0.63

: number of animals; MMFD: mean-myelinated fiber diameter; AD: axon diameter, MSD: myelin sheath diameter. Data are presented as mean ± SEM. *, **, and **** as compared to control group. ##, ###, and ####, as compared to vehicle group.