The Scientific World Journal / 2014 / Article / Tab 1

Research Article

Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 1

Effects of diclofenac, -LA, selenite, Vit C, Vit E, or zinc on paw thickness increase after 3 hr in a rat carrageenan-induced paw edema model.

GroupsPaw edema (thickness increase cm after 3 hr) Inhibition %

Carrageenan (50  L of 1% solution) 0.26 ± 0.063
Diclofenac (5 mg/kg, per os) 38%
-LA (50 mg/kg, IP) 23%
Se (2.5 mg/kg, po) 19%
Vit C (1 g/kg, po) 19%
Vit E (300 mg/kg, po) 31%
ZnSO4 (25 mg/kg, po) 23%

Values are means of 8 rats (±SD).
Value significantly different from carrageenan control ( ).
Value significantly different from diclofenac group ( ).