Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 1

Effects of diclofenac, 𝛼-LA, selenite, Vit C, Vit E, or zinc on paw thickness increase after 3 hr in a rat carrageenan-induced paw edema model.

Groups	Paw edema (thickness increase [cm] after 3 hr)	Inhibition %
Carrageenan (50 𝜇L of 1% solution)	0.26 ± 0.063
Diclofenac (5 mg/kg, per os)	0.16±0.001^#	38%
𝛼-LA (50 mg/kg, IP)	0.20±0.047^#a	23%
Se (2.5 mg/kg, po)	0.21±0.043^#a	19%
Vit C (1 g/kg, po)	0.21±0.038^#a	19%
Vit E (300 mg/kg, po)	0.18±0.031^#a	31%
ZnSO4 (25 mg/kg, po)	0.20±0.044^#a	23%

Values are means of 8 rats (±SD).
#Value significantly different from carrageenan control (𝑃<0.05).
aValue significantly different from diclofenac group (𝑃<0.05).