Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 3

Effects of diclofenac, 𝛼-LA, selenite, Vit C, Vit E, or zinc on plasma levels of MDA, hemolysate GSH, and erythrocyte SOD activity in a rat carrageenan-induced paw edema model.

Groups	MDA (nmol/mL)	GSH (mg %)	SOD (U/g Hb)
Normal (50 𝜇L saline)	0.21±0.038	2.03±0.21	3.95±0.91
Carrageenan (50 𝜇L of 1% solution)	0.59±0.06^∗	0.55±0.26^∗	0.55±0.21^∗
Diclofenac (5 mg/kg, per os)	0.26±0.05^#	3.16±0.34^∗#	1.61±0.16^∗#
𝛼-LA (50 mg/kg, IP)	0.31±0.09^∗#	1.19±0.26^∗#a	3.93±0.87^#a
Se (2.5 mg/kg, po)	0.29±0.02^∗#	1.59±0.12^∗#a	2.10±0.44^∗#a
Vit C (1 g/kg, po)	0.26±0.03^#	1.69±0.30^∗#a	2.59±0.32^∗#a
Vit E (300 mg/kg, po)	0.19±0.03^#a	1.35±0.07^∗#a	1.44±0.25^∗#
ZnSO4 (25 mg/kg, po)	0.33±0.05^∗#a	1.20±0.16^∗#a	2.23±0.57^∗#a

Values are means of 8 rats (±SD).
∗Value is significantly different from normal control (𝑃<0.05).
#Value is significantly different from carrageenan control (𝑃<0.05).
aValue is significantly different from diclofenac group (𝑃<0.05).