Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C

Figure 2

Effects of Antrodia camphorata on MAPK activation in collagen-activated platelets. Washed platelets (1.2 × 10⁹ cells/mL) were preincubated with 112 or 224 μg/mL of Antrodia camphorate and subsequently treated with 1 μg/mL of collagen to induce platelet activation. The platelets were collected, and the phosphorylation of (a) p38, (b) ERK, or (c) JNK in the subcellular extracts was analyzed. Data are presented as the mean ± SEM (; , , and , compared with solvent control platelets).

(a)

(b)

(c)