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The Scientific World Journal
Volume 2014, Article ID 746874, 6 pages
Research Article

Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

1Department of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia
2Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
3Department of Pediatric Dentistry, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia
4School of Medicine, Institute of Pathology, University of Zagreb, 10000 Zagreb, Croatia

Received 31 July 2014; Revised 8 September 2014; Accepted 17 September 2014; Published 29 October 2014

Academic Editor: Niroshani Soysa

Copyright © 2014 Marinka Mravak-Stipetić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (), plasma cells (), and granulocytes () in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.