The Scientific World Journal / 2014 / Article / Tab 2 / Review Article
Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More Table 2 Studies comparing the efficacy of short-course versus long-course antimicrobial regimens for the treatment of CAP, using the same dose of the same drug for a different length of time.
Study
Population Short-course regimen* Long-course regimen* Siegel et al. 1999 [16 ] 52 Adult inpatients Cefuroxime 750 mg IV every 8 h for 2 d, then cefuroxime axetil 500 mg every 12 h PO for 5 d Cefuroxime 750 mg IV every 8 h for 2 d, then cefuroxime axetil 500 mg every 12 h PO for 8 d Léophonte et al. 2002 [15 ] 244 Adult inpatients Ceftriaxone 1 g IV once daily for 5 d Ceftriaxone 1 g IV once daily for 10 d Tellier et al. 2004 [20 ] 388 Adult inpatients and outpatients Telithromycin 800 mg PO once daily for 5 d Telithromycin 800 mg PO once daily for 7 d El Moussaoui et al. 2006 [14 ] 119 Adult inpatients Amoxicillin 1 g IV every 6 h for 3 d Amoxicillin 1 g IV every 6 h for 3 d, then amoxicillin 750 mg PO every 8 h for 5 d File Jr. et al. 2007 [22 ] 510 Adult outpatients Gemifloxacin 320 mg PO once daily for 5 d Gemifloxacin 320 mg PO once daily for 7 d
No statistically significant differences in cure rates.