Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More

Table 2

Studies comparing the efficacy of short-course versus long-course antimicrobial regimens for the treatment of CAP, using the same dose of the same drug for a different length of time.

Study	𝑁	Population	Short-course regimen*	Long-course regimen*
Siegel et al. 1999; [16]	52	Adult inpatients	Cefuroxime 750 mg IV every 8 h for 2 d, then cefuroxime axetil 500 mg every 12 h PO for 5 d	Cefuroxime 750 mg IV every 8 h for 2 d, then cefuroxime axetil 500 mg every 12 h PO for 8 d
Léophonte et al. 2002; [15]	244	Adult inpatients	Ceftriaxone 1 g IV once daily for 5 d	Ceftriaxone 1 g IV once daily for 10 d
Tellier et al. 2004; [20]	388	Adult inpatients and outpatients	Telithromycin 800 mg PO once daily for 5 d	Telithromycin 800 mg PO once daily for 7 d
El Moussaoui et al. 2006; [14]	119	Adult inpatients	Amoxicillin 1 g IV every 6 h for 3 d	Amoxicillin 1 g IV every 6 h for 3 d, then amoxicillin 750 mg PO every 8 h for 5 d
File Jr. et al. 2007; [22]	510	Adult outpatients	Gemifloxacin 320 mg PO once daily for 5 d	Gemifloxacin 320 mg PO once daily for 7 d

∗No statistically significant differences in cure rates.