Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More

Table 3

Studies comparing the efficacy of short-course versus long-course antibiotic regimens for the treatment of CAP, using different antimicrobial agents.

Study	𝑁	Population	Short-course regimen*	Long-course regimen*
Schonwald et al.; 1990 [31]	101	Adult inpatients and outpatients	Azithromycin PO 500 mg on day 1, 250 mg on days 2 to 5	Erythromycin 500 mg PO once daily for 10 d
Bohte et al. 1995; [25]	40	Adult inpatients	Azithromycin PO 500 mg twice daily on day 1, once daily on days 2 to 5	Erythromycin 500 mg PO once daily for 10 d
Schonwald et al. 1994; [30]	150	Adult inpatients	Azithromycin 500 mg PO once daily for 3 d	Roxithromycin 150 mg PO twice daily for 10 d
Rizzato et al. 1995; [29]	40	Adult inpatients	Azithromycin 500 mg PO once daily for 3 d	Clarithromycin 250 mg PO twice daily for at least 8 d
O’Doherty and Muller 1998[28]	203	Adult outpatients	Azithromycin 500 mg PO once daily for 3 d	Clarithromycin 250 mg PO twice daily for 10 d
D’Ignazio et al. 2005; [32]	427	Adult outpatients	Azithromycin microspheres, a single 2 g dose PO	Levofloxacin 500 mg PO once daily for 7 d
Drehobl et al. 2005; [33]	501	Adult outpatients	Azithromycin microspheres, a single 2 g dose PO	Clarithromycin (extended-release formulation) 1 g PO once daily for 7 d
Léophonte et al. 2004; [36]	324	Adult inpatients and outpatients	Gemifloxacin 320 mg PO once daily for 7 d	Amoxicillin/clavulanate 1 g/125 mg PO three times daily for 10 d
Tellier et al. 2004; [20]	575	Adult inpatients and outpatients	Telithromycin 800 mg PO once daily for 5 d or 7 d	Clarithromycin 500 mg PO twice daily for 10 d

∗No statistically significant differences in cure rates.