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The Scientific World Journal
Volume 2014, Article ID 760734, 9 pages
Review Article

HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models

1National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, China
2School of Agroforestry and Medicine, The Open University of China, Beijing 100039, China
3Department of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA

Received 15 June 2014; Accepted 26 November 2014; Published 15 December 2014

Academic Editor: Esteban Martinez

Copyright © 2014 Jing Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission.