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The Scientific World Journal
Volume 2014, Article ID 768323, 10 pages
http://dx.doi.org/10.1155/2014/768323
Review Article

Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae

1Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 15 September 2013; Accepted 1 December 2013; Published 2 January 2014

Academic Editors: L. Eisenbach and U. Naumann

Copyright © 2014 Soheil Zorofchian Moghadamtousi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Atawodi, “Nigerian foodstuffs with prostate cancer chemopreventive polyphenols,” Infectious Agents and Cancer, vol. 6, supplement 2, article S9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. E. A. Perez, “Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer,” Breast Cancer Research and Treatment, vol. 114, no. 2, pp. 195–201, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Kranz and M. Dobbelstein, “A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy,” Cell Cycle, vol. 11, no. 11, pp. 2053–2054, 2012. View at Publisher · View at Google Scholar
  4. S. Elmore, “Apoptosis: a review of programmed cell death,” Toxicologic Pathology, vol. 35, no. 4, pp. 495–516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. H. F. Ji, X. J. Li, and H. Y. Zhang, “Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?” EMBO Reports, vol. 10, no. 3, pp. 194–200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Yang, M. Zeng, S. Dong, Z. Liu, and R. Li, “Anti-proliferative activity of phlorotannin extracts from brown algae Laminaria japonica Aresch,” Chinese Journal of Oceanology and Limnology, vol. 28, no. 1, pp. 122–130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Pangestuti and S. K. Kim, “Biological activities and health benefit effects of natural pigments derived from marine algae,” Journal of Functional Foods, vol. 3, no. 4, pp. 255–266, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Yamamoto and H. Maruyama, “Effect of dietary seaweed preparations on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats,” Cancer Letters, vol. 26, no. 3, pp. 241–251, 1985. View at Google Scholar · View at Scopus
  9. I. Yamamoto, H. Maruyama, and M. Moriguchi, “The effect of dietary seaweeds on 7,12-dimethyl-benz[a]anthracene-induced mammary tumorigenesis in rats,” Cancer Letters, vol. 35, no. 2, pp. 109–118, 1987. View at Google Scholar · View at Scopus
  10. N. Bourgougnon, C. Roussakis, J. M. Kornprobst, and M. Lahaye, “Effects in vitro of sulfated polysaccharide from Schizymenia dubyi (Rhodophyta, Gigartinales) on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6),” Cancer Letters, vol. 85, no. 1, pp. 87–92, 1994. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. S. Mayer and K. R. Gustafson, “Marine pharmacology in 2000: antitumor and cytotoxic compounds,” International Journal of Cancer, vol. 105, no. 3, pp. 291–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. S. B. Khan, C. S. Kong, J. A. Kim, and S. K. Kim, “Protective effect of amphiroa dilatata on ROS induced oxidative damage and MMP expressions in HT1080 cells,” Biotechnology and Bioprocess Engineering, vol. 15, no. 1, pp. 191–198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Asai, T. Sugawara, H. Ono, and A. Nagao, “Biotransformation of fucoxanthinol into amarouciaxanthin a in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites,” Drug Metabolism and Disposition, vol. 32, no. 2, pp. 205–211, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. M. J. Kwon and T. J. Nam, “Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines,” Life Sciences, vol. 79, no. 20, pp. 1956–1962, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Zubia, M. S. Fabre, V. Kerjean et al., “Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts,” Food Chemistry, vol. 116, no. 3, pp. 693–701, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Taskin, Z. Caki, M. Ozturk, and E. Taskin, “Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea,” African Journal of Biotechnology, vol. 9, no. 27, pp. 4272–4277, 2010. View at Google Scholar · View at Scopus
  17. Y. Athukorala, K. N. Kim, and Y. J. Jeon, “Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava,” Food and Chemical Toxicology, vol. 44, no. 7, pp. 1065–1074, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Noda, H. Amano, K. Arashima, and K. Nisizawa, “Antitumor activity of marine algae,” in Proceedings of the 13th International Seaweed Symposium, pp. 577–584, Springer, 1990. View at Publisher · View at Google Scholar
  19. H. Funahashi, T. Imai, Y. Tanaka et al., “Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors in rats,” Japanese Journal of Cancer Research, vol. 90, no. 9, pp. 922–927, 1999. View at Google Scholar · View at Scopus
  20. H. Funahashi, T. Imai, T. Mase et al., “Seaweed prevents breast cancer?” Cancer Science, vol. 92, no. 5, pp. 483–487, 2001. View at Publisher · View at Google Scholar
  21. E. B. Damonte, M. C. Matulewicz, and A. S. Cerezo, “Sulfated seaweed polysaccharides as antiviral agents,” Current Medicinal Chemistry, vol. 11, no. 18, pp. 2399–2419, 2004. View at Google Scholar · View at Scopus
  22. A. Cumashi, N. A. Ushakova, M. E. Preobrazhenskaya et al., “A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds,” Glycobiology, vol. 17, no. 5, pp. 541–552, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Chevolot, B. Mulloy, J. Ratiskol, A. Foucault, and S. Colliec-Jouault, “A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae,” Carbohydrate Research, vol. 330, no. 4, pp. 529–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Teruya, T. Konishi, S. Uechi, H. Tamaki, and M. Tako, “Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells,” International Journal of Biological Macromolecules, vol. 41, no. 3, pp. 221–226, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Yamamoto, M. Takahashi, and T. Suzuki, “Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from sargassum kjellmanianum,” Japanese Journal of Experimental Medicine, vol. 54, no. 4, pp. 143–151, 1984. View at Google Scholar · View at Scopus
  26. D. R. Coombe, C. R. Parish, I. A. Ramshaw, and J. M. Snowden, “Analysis of the inhibition of tumour metastasis by sulphated polysaccharides,” International Journal of Cancer, vol. 39, no. 1, pp. 82–88, 1987. View at Google Scholar · View at Scopus
  27. Z. C. Zhuang Cun, H. Itoh, T. Mizuno, and H. Ito, “Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii),” Bioscience, Biotechnology and Biochemistry, vol. 59, no. 4, pp. 563–567, 1995. View at Google Scholar · View at Scopus
  28. S. Koyanagi, N. Tanigawa, H. Nakagawa, S. Soeda, and H. Shimeno, “Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities,” Biochemical Pharmacology, vol. 65, no. 2, pp. 173–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Ye, Y. Li, K. Teruya et al., “Enzyme-digested fucoidan extracts derived from seaweed Mozuku of Cladosiphon novae-caledoniae kylin inhibit invasion and angiogenesis of tumor cells,” Cytotechnology, vol. 47, no. 1 3, pp. 117–126, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Itoh, H. Noda, H. Amano, C. Zhuaug, T. Mizuno, and H. Ito, “Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of phaeophyceae,” Anticancer Research, vol. 13, no. 6, pp. 2045–2052, 1993. View at Google Scholar · View at Scopus
  31. H. Maruyama, H. Tamauchi, M. Hashimoto, and T. Nakano, “Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida,” In Vivo, vol. 17, no. 3, pp. 245–249, 2003. View at Google Scholar · View at Scopus
  32. T. V. Alekseyenko, S. Y. Zhanayeva, A. A. Venediktova et al., “Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga,” Bulletin of Experimental Biology and Medicine, vol. 143, no. 6, pp. 730–732, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Riou, S. Colliec-Jouault, D. Pinczon Du Sel et al., “Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line,” Anticancer Research, vol. 16, no. 3, pp. 1213–1218, 1996. View at Google Scholar · View at Scopus
  34. Y. Aisa, Y. Miyakawa, T. Nakazato et al., “Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways,” American Journal of Hematology, vol. 78, no. 1, pp. 7–14, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Kawamoto, Y. Miki, T. Kimura et al., “Effects of fucoidan from Mozuku on human stomach cell lines,” Food Science and Technology Research, vol. 12, no. 3, pp. 218–222, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. Yamasaki-Miyamoto, M. Yamasaki, H. Tachibana, and K. Yamada, “Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells,” Journal of Agricultural and Food Chemistry, vol. 57, no. 18, pp. 8677–8682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. M. I. Bilan, A. A. Grachev, N. E. Ustuzhanina, A. S. Shashkov, N. E. Nifantiev, and A. I. Usov, “A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.,” Carbohydrate Research, vol. 339, no. 3, pp. 511–517, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. E. J. Kim, S. Y. Park, J. Y. Lee, and J. H. Y. Park, “Fucoidan present in brown algae induces apoptosis of human colon cancer cells,” BMC Gastroenterology, vol. 10, article 96, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. J. H. Hyun, S. C. Kim, J. I. Kang et al., “Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells,” Biological and Pharmaceutical Bulletin, vol. 32, no. 10, pp. 1760–1764, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Synytsya, W. J. Kim, S. M. Kim et al., “Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida,” Carbohydrate Polymers, vol. 81, no. 1, pp. 41–48, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Hejna, M. Raderer, and C. C. Zielinski, “Inhibition of metastases by anticoagulants,” Journal of the National Cancer Institute, vol. 91, no. 1, pp. 22–36, 1999. View at Google Scholar · View at Scopus
  42. A. Philchenkov, M. Zavelevich, T. Imbs, T. Zvyagintseva, and T. Zaporozhets, “Sensitization of human malignant lymphoid cells to etoposide by fucoidan, a brown seaweed polysaccharide,” Experimental Oncology, vol. 29, no. 3, pp. 181–185, 2007. View at Google Scholar · View at Scopus
  43. G. van Poppel and H. van den Berg, “Vitamins and cancer,” Cancer Letters, vol. 114, no. 1-2, pp. 195–202, 1997. View at Publisher · View at Google Scholar · View at Scopus
  44. S. K. Das, T. Hashimoto, K. Shimizu et al., “Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1,” Biochimica et Biophysica Acta, vol. 1726, no. 3, pp. 328–335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Ishikawa, S. Tafuku, T. Kadekaru et al., “Antiadult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol,” International Journal of Cancer, vol. 123, no. 11, pp. 2702–2712, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Okuzumi, H. Nishino, M. Murakoshi et al., “Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells,” Cancer Letters, vol. 55, no. 1, pp. 75–81, 1990. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Okuzumi, T. Takahashi, T. Yamane et al., “Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N′-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis,” Cancer Letters, vol. 68, no. 2-3, pp. 159–168, 1993. View at Google Scholar · View at Scopus
  48. H. Nishino, “Cancer prevention by carotenoids,” Mutation Research, vol. 402, no. 1-2, pp. 159–163, 1998. View at Publisher · View at Google Scholar · View at Scopus
  49. J. M. Kim, S. Araki, D. J. Kim et al., “Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation,” Carcinogenesis, vol. 19, no. 1, pp. 81–85, 1998. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Hosokawa, S. Wanezaki, K. Miyauchi et al., “Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60,” Food Science and Technology Research, vol. 5, no. 3, pp. 243–246, 1999. View at Google Scholar · View at Scopus
  51. E. Kotake-Nara, M. Kushiro, H. Zhang, T. Sugawara, K. Miyashita, and A. Nagao, “Carotenoids affect proliferation of human prostate cancer cells,” Journal of Nutrition, vol. 131, no. 12, pp. 3303–3306, 2001. View at Google Scholar · View at Scopus
  52. M. Hosokawa, M. Kudo, H. Maeda, H. Kohno, T. Tanaka, and K. Miyashita, “Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells,” Biochimica et Biophysica Acta, vol. 1675, no. 1 3, pp. 113–119, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. E. Kotake-Nara, A. Asai, and A. Nagao, “Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells,” Cancer Letters, vol. 220, no. 1, pp. 75–84, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. E. Kotake-Nara, T. Sugawara, and A. Nagao, “Antiproliferative effect of neoxanthin and fucoxanthin on cultured cells,” Fisheries Science, vol. 71, no. 2, pp. 459–461, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Yoshiko and N. Hoyoko, “Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells,” In Vivo, vol. 21, no. 2, pp. 305–309, 2007. View at Google Scholar · View at Scopus
  56. S. K. Das, T. Hashimoto, and K. Kanazawa, “Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D,” Biochimica et Biophysica Acta, vol. 1780, no. 4, pp. 743–749, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. Y. Hinuma, K. Nagata, and M. Hanaoka, “Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera,” Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 10, pp. 6476–6480, 1981. View at Google Scholar · View at Scopus
  58. R. X. Yu, X. M. Hu, S. Q. Xu, Z. J. Jiang, and W. Yang, “Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway,” European Journal of Pharmacology, vol. 657, no. 1 3, pp. 10–19, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Sugawara, K. Matsubara, R. Akagi, M. Mori, and T. Hirata, “Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol,” Journal of Agricultural and Food Chemistry, vol. 54, no. 26, pp. 9805–9810, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. P. K. Duitsman, A. B. Barua, B. Becker, and J. A. Olson, “Effects of epoxycarotenoids, β-carotene, and retinoic acid on the differentiation and viability of the leukemia cell line NB4 in vitro,” International Journal for Vitamin and Nutrition Research, vol. 69, no. 5, pp. 303–308, 1999. View at Google Scholar · View at Scopus