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The Scientific World Journal
Volume 2014 (2014), Article ID 768681, 6 pages
http://dx.doi.org/10.1155/2014/768681
Review Article

Mink S38G Gene Polymorphism and Atrial Fibrillation in the Chinese Population: A Meta-Analysis of 1871 Participants

1Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Received 13 November 2013; Accepted 5 January 2014; Published 16 February 2014

Academic Editors: M. Fontès and A. Latorre

Copyright © 2014 Yan-yan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mink gene S38G polymorphism in the β-subunit of slow activating component of the delayed rectifier potassium channel current potassium channel has been associated with increased atrial fibrillation (AF) risk. However, the individual studies results were still controversial. To investigate the association of Mink S38G gene polymorphisms with AF, a meta-analysis including 1871 subjects from six individual studies was conducted. Mink S38G gene polymorphism was significantly related to AF under allelic (OR: 1.380, 95% CI:  , ), recessive (OR: 1.193, 95% CI:  , ), dominant (OR: 1.057, 95% CI:  , ), additive (OR: 1.105, 95% CI:  , ), homozygous (OR: 1.128, 95% CI:  , ), and heterozygous genetic models (OR: 1.078, 95% CI:  , ). A significant association between Mink S38G gene polymorphism and AF risk was found. G allele carriers may predispose to AF.