Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis
Mechanism of vascular changes by platelet-derived microparticles (PMPs). PMPs activate monocytes by a reaction between P-selectin and PSGL-1 (P-selectin glycoprotein ligand-1). Activated monocytes induce expression on the cell surface of tissue factor (TF) and CD11b. Activated monocytes also induce release of monocyte-derived microparticles (MMPs). PMPs induce COX-2 production in endothelial cells. PMPs enhance expression of CD54 (ICAM-1) on the endothelial surface. Activated endothelial cells also induce release of endothelial cell-derived microparticles (EMPs), enhancing adhesion between endothelial cells and monocytes. Finally, monocytes induce migration of endothelial cells, resulting in vascular changes. Abbreviations: arachidonic acid (AA); protein kinase C (PKC); mitogen-activated protein kinase (MAPK) (adapted from Nomura, 2001 ).
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