Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014 (2014), Article ID 794756, 8 pages
http://dx.doi.org/10.1155/2014/794756
Research Article

Blocked Autophagy by miR-101 Enhances Osteosarcoma Cell Chemosensitivity In Vitro

1The Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China
2The Department of Cervical Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
3The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
4The Department of Anesthesiology, The PLA 264 Hospital, Taiyuan 030001, China

Received 12 April 2014; Accepted 26 May 2014; Published 9 June 2014

Academic Editor: Qinghua Cui

Copyright © 2014 Zhiqiang Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Ottaviani and N. Jaffe, “The epidemiology of osteosarcoma,” in Pediatric and Adolescent Osteosarcoma, pp. 3–13, Springer, 2010. View at Google Scholar
  2. A. J. Chou, D. S. Geller, and R. Gorlick, “Therapy for osteosarcoma: where do we go from here?” Pediatric Drugs, vol. 10, no. 5, pp. 315–327, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Bacci, A. Longhi, M. Versari, M. Mercuri, A. Briccoli, and P. Picci, “Prognostic factors for osteosarcoma of the extremity trerated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution,” Cancer, vol. 106, no. 5, pp. 1154–1161, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. J. Chou, P. B. Merola, L. H. Wexler et al., “Treatment of osteosarcoma at first recurrence after contemporary therapy: the memorial sloan-kettering cancer center experience,” Cancer, vol. 104, no. 10, pp. 2214–2221, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. R. L. Deter and C. de Duve, “Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes,” The Journal of Cell Biology, vol. 33, no. 2, pp. 437–449, 1967. View at Google Scholar · View at Scopus
  6. P. A. Jaeger and T. W. Coray, “All-you-can-eat: autophagy in neurodegeneration and neuroprotection,” Molecular Neurodegeneration, vol. 4, no. 1, pp. 16–38, 2009. View at Google Scholar · View at Scopus
  7. D. Gibbings, S. Mostowy, F. Jay, Y. Schwab, P. Cossart, and O. Voinnet, “Selective autophagy degrades DICER and AGO2 and regulates miRNA activity,” Nature Cell Biology, vol. 14, no. 12, pp. 1314–1321, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Mathew, V. Karantza-Wadsworth, and E. White, “Role of autophagy in cancer,” Nature Reviews Cancer, vol. 7, no. 12, pp. 961–967, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. E. White and R. S. DiPaola, “The double-edged sword of autophagy modulation in cancer,” Clinical Cancer Research, vol. 15, no. 17, pp. 5308–5316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Korkaya and M. S. Wicha, “Inflammation and autophagy conspire to promote tumor growth,” Cell Cycle, vol. 10, no. 16, pp. 2623–2624, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Chen, Y. Z. Jiang, L. Huang et al., “The residual tumor autophagy marker LC3B serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy,” Clinical Cancer Research, vol. 19, pp. 6853–6862, 2013. View at Google Scholar
  12. S. Chen and J. L. Guan, “Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer,” Cancer Discovery, vol. 3, pp. 1225–1227, 2013. View at Google Scholar
  13. D. Gozuacik and A. Kimchi, “Autophagy as a cell death and tumor suppressor mechanism,” Oncogene, vol. 23, no. 16, pp. 2891–2906, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Huang, K. Liu, Y. Yu et al., “Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma,” Autophagy, vol. 8, no. 2, pp. 275–277, 2012. View at Google Scholar · View at Scopus
  15. H. Osada and T. Takahashi, “MicroRNAs in biological processes and carcinogenesis,” Carcinogenesis, vol. 28, no. 1, pp. 2–12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. R. T. Lima, S. Busacca, G. M. Almeida, G. Gaudino, D. A. Fennell, and M. H. Vasconcelos, “MicroRNA regulation of core apoptosis pathways in cancer,” European Journal of Cancer, vol. 47, no. 2, pp. 163–174, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. L. B. Frankel and A. H. Lund, “MicroRNA regulation of autophagy,” Carcinogenesis, vol. 33, no. 11, pp. 2018–2025, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. L. B. Frankel, J. Wen, M. Lees et al., “MicroRNA-101 is a potent inhibitor of autophagy,” The EMBO Journal, vol. 30, no. 22, pp. 4628–4641, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. G. Bader, D. Brown, J. Stoudemire, and P. Lammers, “Developing therapeutic microRNAs for cancer,” Gene Therapy, vol. 18, no. 12, pp. 1121–1126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. S. B. Thorsen, S. Obad, N. F. Jensen, J. Stenvang, and S. Kauppinen, “The therapeutic potential of MicroRNAs in cancer,” Cancer Journal, vol. 18, no. 3, pp. 275–284, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Zou, L. Wu, H. Ding et al., “MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy,” The Journal of Biological Chemistry, vol. 287, no. 6, pp. 4148–4156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Wang, J. Zhang, L. Zhang et al., “MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells,” Gastroenterology, vol. 145, pp. 1133.e12–1143.e12, 2013. View at Google Scholar
  23. S. Paglin, T. Hollister, T. Delohery et al., “A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles,” Cancer Research, vol. 61, no. 2, pp. 439–444, 2001. View at Google Scholar · View at Scopus
  24. S. Daido, T. Kanzawa, A. Yamamoto, H. Takeuchi, Y. Kondo, and S. Kondo, “Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells,” Cancer Research, vol. 64, no. 12, pp. 4286–4293, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. A. J. Chou and R. Gorlick, “Chemotherapy resistance in osteosarcoma: current challenges and future directions,” Expert Review of Anticancer Therapy, vol. 6, no. 7, pp. 1075–1085, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Zhang, H. Hu, L. Song, L. Cai, R. Wei, and W. Jin, “Epirubicin-mediated expression of miR-302b is involved in osteosarcoma apoptosis and cell cycle regulation,” Toxicology Letters, vol. 222, no. 1, pp. 1–9, 2013. View at Publisher · View at Google Scholar · View at Scopus