Variability in Estimated Glomerular Filtration Rate by Area under the Curve Predicts Renal Outcomes in Chronic Kidney Disease

Table 4

Risk association between eGFR variability and renal end points using Cox proportion hazard model analysis.

Method	HR (95% CI)	value
Initial eGFR AUC%_12M	0.962 (0.955–0.969)	<0.001
Peak eGFR AUC%_12M	0.973 (0.966–0.980)	<0.001
eGFR slope_12M	0.358 (0.309–0.414)	<0.001

Values expressed as hazard ratio (HR) and 95% confidence interval (CI).
Covariates in the multivariate model included age, sex, a history of diabetes, hypertension, and cardiovascular disease, systolic and diastolic blood pressure, body mass index, albumin, fasting glucose, triglyceride, total cholesterol, hemoglobin, eGFR, total calcium, phosphorous, CaXP product, uric acid, urine protein-to-creatinine ratio, ACEI and/or ARB use, and acute kidney injury episode.