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The Scientific World Journal
Volume 2014 (2014), Article ID 802437, 7 pages
http://dx.doi.org/10.1155/2014/802437
Review Article

Next Generation Sequencing: Potential and Application in Drug Discovery

1Hematological Facility, Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India
2Academy of Scientific and Innovative Research, New Delhi 110 001, India
3Jaipur National University, Jaipur, Rajasthan 302017, India

Received 12 August 2013; Accepted 18 October 2013; Published 5 February 2014

Academic Editors: Z. P. Çakar and S. Rodríguez-Couto

Copyright © 2014 Navneet Kumar Yadav et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The world has now entered into a new era of genomics because of the continued advancements in the next generation high throughput sequencing technologies, which includes sequencing by synthesis-fluorescent in situ sequencing (FISSEQ), pyrosequencing, sequencing by ligation using polony amplification, supported oligonucleotide detection (SOLiD), sequencing by hybridization along with sequencing by ligation, and nanopore technology. Great impacts of these methods can be seen for solving the genome related problems of plant and animal kingdom that will open the door of a new era of genomics. This may ultimately overcome the Sanger sequencing that ruled for 30 years. NGS is expected to advance and make the drug discovery process more rapid.