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The Scientific World Journal
Volume 2014, Article ID 804738, 9 pages
Research Article

HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China

1Department of Radiation Oncology, Qilu Hospital of Shandong University, No. 44 Wenhua Xi Road, Jinan 250012, China
2Department of Oncology, Liaocheng People’s Hospital, Liaocheng 252000, China
3Department of Oncology, The First Hospital of Zibo, Zibo 255000, China
4Department of Radiation Oncology, Cancer Hospital, General Hospital of Ningxia Medical University, Yinchuan 750000, China
5Department of Ultrasound, Liaocheng People’s Hospital, Liaocheng 252000, China
6Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000, China

Received 15 September 2013; Accepted 5 December 2013; Published 12 January 2014

Academic Editors: D. H. Dinh and J. Hofmann

Copyright © 2014 Fangli Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Human papillomavirus (HPV) as a risk factor for esophageal squamous cell carcinoma (ESCC) has previously been studied, but importance of HPV status in ESCC for prognosis is less clear. Methods. A total of 105 specimens with ESCC were tested by in situ hybridization for HPV 16/18 and immunohistochemistry for p16 expression. The 5-year overall survival (OS) and progression-free survival were calculated in relation to these markers and the Cox proportional hazards model was used to determine the hazard ratio (HR) of variables in univariate and multivariate analysis. Results. HPV was detected in 27.6% (29) of the 105 patients with ESCC, and all positive cases were HPV-16. Twenty-five (86.2%) of the 29 HPV-positive tumors were stained positive for p16. HPV infected patients had better 5-year rates of OS (65.9% versus 43.4% among patients with HPV-negative tumors; P = 0.002 by the log-rank test) and had a 63% reduction in the risk of death (adjusted HR = 0.37, 95% CI = 0.16 to 0.82, and P = 0.01). Conclusions. HPV infection may be one of many factors contributing to the development of ESCC and tumor HPV status is an independent prognostic factor for survival among patients with ESCC.