HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China

Table 3

Cox univariate analysis for 5-year survival and progression-free survival in the study patients with esophageal squamous cell carcinoma.

Parameters	Univariate analysis
	5-yr overall survival			5-yr progression-free survival
	HR	95% CI	P value	HR	95% CI	P value
Gender	1.29	0.68–2.47	0.44	1.32	0.71–2.45	0.38
Male versus female
Age	0.98	0.56–1.70	0.93	0.85	0.51–1.44	0.55
<60 versus ≥60
Location	0.75	0.30–1.89	0.54	0.66	0.28–1.55	0.34
Cervical/upper versus middle/low
Differentiation	1.01	0.56–1.81	0.99	1.12	0.58–2.14	0.74
Well/moderate versus poor
pT status	3.44	1.85–6.40	<0.001	2.42	1.40–4.19	0.002
T1/T2 versus T3/T4
pN status	2.71	1.55–4.73	<0.001	2.79	1.66–4.72	0.001
N0 versus N1/N2/N3
TNM stage	3.04	1.74–5.32	<0.001	2.66	1.57–4.50	<0.001
I/II versus III/IV
Adjuvant therapy	0.75	0.54–1.53	0.35	0.51	0.45–1.28	0.12
No versus yes
Pack-years of smoking	1.88	1.03–3.45	0.04	1.96	1.11–3.45	0.02
<20 versus ≥20
Alcohol intake (kg/day)	1.66	0.95–2.92	0.08	1.61	0.95–2.73	0.06
<0.025 versus ≥0.025
Tumor HPV status	0.31	0.14–0.68	0.004	0.33	0.16–0.67	0.002
Negative versus positive
Tumor HPV status	3.26	1.46–7.25	0.004	3.01	1.50–6.17	0.002
Positive versus negative

HR: hazard ratio; CI: confidence interval; a pack-year: the equivalent of smoking one pack of cigarettes per day for 1 year.