Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models

Table 5

Brain areas activated by X. laevigata leaf essential oil (EOX) in mice.

Treatment	Dose	FOS positive cells
	(mg/kg)	Olfactory bulb	Piriform cortex	Periaqueductal gray
Vehicle	—	3.5 ± 0.6	3.0 ± 1.4	4.2 ± 1.3
EOX	12.5	11.7 ± 2.6	8.0 ± 1.7	23.7 ± 5.2^a
EOX	25	22.0 ± 5.4^a	29.5 ± 3.6^b	28.7 ± 1.1^b
EOX	50	25.7 ± 6.4^b	34.0 ± 9.4^b	19.2 ± 3.6^a

𝑛=4, per group; values represent mean ± S.E.M. ^a𝑃<0.01 or ^b𝑃<0.001 (one-way ANOVA and Tukey’s test), significantly different from vehicle-treated mice.