Evaluation of In Vitro Antimalarial Activity of Different Extracts of Artemisia aucheri Boiss. and A. armeniaca Lam. and Fractions of the Most Potent Extracts

Table 1

The 50% and 90% inhibition concentrations (mg/mL) of different extracts and fractions of A. armeniaca and A. aucheri in 𝛽-hematin formation assay.

Plants	Extracts/fractions	Yields (%)	IC50 (mg/mL)^a	IC90 (mg/mL)^a
Artemisia aucheri; (aerial parts)	Petroleum ether	1.11	4.79±0.92	10.25±2.91
	Dichloromethane	4.46	1.83±0.03	2.62±0.09
	Ethyl acetate	0.46	—	—
	Ethanol	9.09	—	—
	Ethanol-water	7.27	—	—
Artemisia armeniaca; (aerial parts)	Petroleum ether	1.88	3.51±0.11	7.96±0.17
	Dichloromethane	1.97	1.36±0.01	2.12±0.04
	Ethyl acetate	0.56	—	—
	Ethanol	2.57	—	—
	Ethanol-water	17.66	—	—
Artemisia aucheri; (DCM fractions)	10% EtOAC/PE	16.86	—	—
	20% EtOAC/PE	8.08	—	—
	40% EtOAC/PE	24.68	—	—
	60% EtOAC/PE	15.06	1.23±0.01	2.13±0.07
	80% EtOAC/PE	7.12	1.38±0.05	2.70±0.44
	100% EtOAC	8.91	1.55±0.01	2.01±0.01
	100% Methanol	10.51	1.45±0.03	2.26±0.05
Artemisia armeniaca; (DCM fractions)	10% EtOAC/PE	3.25	—	—
	20% EtOAC/PE	3.90	—	—
	40% EtOAC/PE	13.88	—	—
	60% EtOAC/PE	7.48	—	—
	80% EtOAC/PE	15.84	0.47±0.006	0.71±0.006
	100% EtOAC	6.49	0.94±0.006	1.26±0.02
	100% Methanol	40.91	—	—
Chloroquine	—	—	0.04±0.002	0.35±0.006

aExperiment was performed in triplicate and expressed as Mean ± SD.