Research Article
Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders
Table 1
Klys/leu powders produced by nanospray drier: process parameters, yield, drug content, and particle size distribution (15% leu and 30% IPA).
| | Batch | (°C) | Total powder concentration (% w/v) | Nozzle (µm) | Yield (%) | (µm) and span | Drug content (% p/p) | Process time (mL/min) |
| | #1 | 110 | 5% | 7 | 87.0 ± 2.8 | 6.6 (1.7) | 79.4 ± 1.5 | 1.11 | | #2 | 110 | 3% | 7 | 82.3 ± 3.2 | 6.2 (1.7) | 77.0 ± 2.1 | 1.11 | | #3 | 110 | 5% | 4 | 62.3 ± 2.8 | 3.2 (1.7) | 82.9 ± 0.8 | 0.13 | | #4 | 110 | 3% | 4 | 43.0 ± 4.2 | —a | 79.2 ± 3.1 | 0.10 | | #5 | 70 | 5% | 4 | 77.6 ± 1.6 | 2.4 (1.7) | 75.3 ± 0.4 | 0.06 | | #6 | 70 | 3% | 4 | 56.7 ± 1.0 | —a | 78.5 ± 1.1 | 0.06 | | #7 | 70 | 1% | 4 | 52.1 ± 1.8 | —a | 80.1 ± 1.3 | 0.08 | | #8 | 60 | 5% | 4 | 27.9 ± 7.1 | —a | 73.5 ± 1.2 | 0.04 | | #9 | 70 | 5% | 5.5 | 68.6 ± 1.9 | 3.1 (2.4) | 72.4 ± 0.6 | 0.33 |
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Powder stickiness prevented measure.
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