Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders

Table 3

Process parameters and physical characteristics of Klys/leu particles sprayed through a surfactant treated nozzle (70°C, 4 µm nozzle): liquid feed composition, yield, and dimensional distribution.

Batch	Total powder concentration (% w/v)	Leu concentration (% w/w)	Water/IPA (% v/v)	Yield (%)	(µm) and span	Process time (mL/min)
#5a	5%	15%	70/30	33.1 ± 9.2	—^a	0.21
#5b	6%	15%	70/30	45.1 ± 3.5	—^a	0.21
#5c	5%	10%	70/30	74.8 ± 2.5	—^a	0.21
#5d	6%	10%	70/30	75.2 ± 1.0	3.01 (1.80)	0.21
#5e	7%	10%	70/30	18.2 ± 7.5	—^a	0.21
#10	6%	15%	100/0	71.7 ± 1.2	3.14 (1.86)	0.14
#11	6%	15%	90/10	75.3 ± 0.5	2.84 (1.63)	0.42
#12	6%	15%	80/20	68.7 ± 2.6	2.94 (1.90)	0.06
#13	6%	10%	90/10	76.2 ± 3.1	2.52 (1.90)	0.21
#14	6%	10%	100/0	65.5 ± 1.5	3.14 (1.69)	0.10

Powder stickiness prevented measure.