The Scientific World Journal / 2014 / Article / Tab 3

Research Article

Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders

Table 3

Process parameters and physical characteristics of Klys/leu particles sprayed through a surfactant treated nozzle (70°C, 4 µm nozzle): liquid feed composition, yield, and dimensional distribution.

BatchTotal powder concentration (% w/v) Leu concentration (% w/w)Water/IPA (% v/v)Yield (%) (µm) and spanProcess time (mL/min)

#5a5%15%70/3033.1 ± 9.2a0.21
#5b6%15%70/3045.1 ± 3.5a0.21
#5c5%10%70/3074.8 ± 2.5a0.21
#5d6%10%70/3075.2 ± 1.03.01 (1.80)0.21
#5e7%10%70/3018.2 ± 7.5a0.21
#106%15%100/071.7 ± 1.23.14 (1.86)0.14
#116%15%90/1075.3 ± 0.52.84 (1.63)0.42
#126%15%80/2068.7 ± 2.62.94 (1.90)0.06
#136%10%90/1076.2 ± 3.12.52 (1.90)0.21
#146%10%100/065.5 ± 1.53.14 (1.69)0.10

Powder stickiness prevented measure.

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