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The Scientific World Journal
Volume 2014, Article ID 849834, 7 pages
Research Article

Validation of a Spanish Version of the Lille Apathy Rating Scale for Parkinson’s Disease

1Neurology Service, Hospital Clinico San Carlos, IdiSSC, Universidad Complutense, Calle Profesor, Martin Lagos s/n, 28040 Madrid, Spain
2Facultad de Ciencias de la Salud, Universidad de Alicante, 03080 Alicante, Spain

Received 4 July 2014; Revised 25 August 2014; Accepted 27 August 2014; Published 14 October 2014

Academic Editor: Francisco Javier Carod-Artal

Copyright © 2014 Rocio García-Ramos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. To date, no rating scales for detecting apathy in Parkinson’s disease (PD) patients have been validated in Spanish. For this reason, the aim of this study was to validate a Spanish version of Lille apathy rating scale (LARS) in a cohort of PD patients from Spain. Participants and Methods. 130 PD patients and 70 healthy controls were recruited to participate in the study. Apathy was measured using the Spanish version of LARS and the neuropsychiatric inventory (NPI). Reliability (internal consistency, test-retest, and interrater reliability) and validity (construct, content, and criterion validity) were measured. Results. Interrater reliability was 0.93. Cronbach’s α for LARS was 0.81. The test-retest correlation coefficient was 0.97. The correlation between LARS and NPI scores was 0.61. The optimal cutoff point under the ROC curve was , whereas the value derived from healthy controls was . The prevalence of apathy in our population tested by LARS was 42%. Conclusions. The Spanish version of LARS is a reliable and useful tool for diagnosing apathy in PD patients. Total LARS score is influenced by the presence of depression and cognitive impairment. However, both disorders are independent identities with respect to apathy. The satisfactory reliability and validity of the scale make it an appropriate instrument for screening and diagnosing apathy in clinical practice or for research purposes.