Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 852104, 6 pages
http://dx.doi.org/10.1155/2014/852104
Research Article

Association of Interleukin-18 Gene Polymorphism with Susceptibility to Visceral Leishmaniasis in Endemic Area of Bihar, an Indian Population

Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221 005, India

Received 30 July 2014; Revised 24 September 2014; Accepted 25 September 2014; Published 22 October 2014

Academic Editor: Hidenori Ohnishi

Copyright © 2014 Dinesh Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. L. Sacks, S. L. Lal, S. N. Shrivastava, J. Blackwell, and F. A. Neva, “An analysis of T cell responsiveness in Indian Kala-azar,” The Journal of Immunology, vol. 138, no. 3, pp. 908–913, 1987. View at Google Scholar · View at Scopus
  2. A. C. White Jr., M. Castes, L. Garcia, D. Trujillo, and L. Zambrano, “Leishmania chagasi antigens recognized in cured visceral leishmaniasis and asymptomatic infection,” American Journal of Tropical Medicine and Hygiene, vol. 46, no. 2, pp. 123–131, 1992. View at Google Scholar · View at Scopus
  3. M. Munder, M. Mallo, K. Eichmann, and M. Modolell, “Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation,” The Journal of Experimental Medicine, vol. 187, no. 12, pp. 2103–2108, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Okamura, S.-I. Kashiwamura, H. Tsutsui, T. Yoshimoto, and K. Nakanishi, “Regulation of interferon-γ production by IL-12 and IL-18,” Current Opinion in Immunology, vol. 10, no. 3, pp. 259–264, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Xu, V. Trajkovic, D. Hunter et al., “IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background,” European Journal of Immunology, vol. 30, no. 11, pp. 3147–3156, 2000. View at Google Scholar
  6. K. Takeda, H. Tsutsui, T. Yoshimoto et al., “Defective NK cell activity and Th1 response in IL-18-deficient mice,” Immunity, vol. 8, no. 3, pp. 383–390, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. S. J. Green, M. S. Meltzer, J. B. Hibbs Jr., and C. A. Nacy, “Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism,” Journal of Immunology, vol. 144, no. 1, pp. 278–283, 1990. View at Google Scholar · View at Scopus
  8. J. C. M. Morel, C. C. Park, J. M. Woods, and A. E. Koch, “A novel role for interleukin-18 in adhesion molecule induction through NF κB and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways,” Journal of Biological Chemistry, vol. 276, no. 40, pp. 37069–37075, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. X. H. Liang, W. Cheung, C. K. Heng, and D. Y. Wang, “Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study,” Biochemical and Biophysical Research Communications, vol. 338, no. 2, pp. 736–741, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Giedraitis, B. He, W.-X. Huang, and J. Hillert, “Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation,” Journal of Neuroimmunology, vol. 112, no. 1-2, pp. 146–152, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Arimitsu, T. Hirano, S. Higa et al., “IL-18 gene polymorphisms affect IL-18 production capability by monocytes,” Biochemical and Biophysical Research Communications, vol. 342, no. 4, pp. 1413–1416, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Kalani, M. Rasouli, A. Moravej, S. Kiany, and H. R. Rahimi, “Association of interleukin-15 single nucleotide polymorphisms with resistance to brucellosis among Iranian patients,” Tissue Antigens, vol. 78, no. 5, pp. 352–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Folwaczny, J. Glas, H.-P. Török et al., “Polymorphisms of the interleukin-18 gene in periodontitis patients,” Journal of Clinical Periodontology, vol. 32, no. 5, pp. 530–534, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Moravej, M. Rasouli, M. Kalani et al., “IL-1β (-511T/C) gene polymorphism not IL-1β (+3953T/C) and LT-α (+252A/G) gene variants confers susceptibility to visceral leishmaniasis,” Molecular Biology Reports, vol. 39, no. 6, pp. 6907–6914, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Moravej, M. Rasouli, S. Asaei, M. Kalani, and Y. Mansoori, “Association of interleukin-18 gene variants with susceptibility to visceral leishmaniasis in Iranian population,” Molecular Biology Reports, vol. 40, no. 6, pp. 4009–4014, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Yoshimoto, H. Tsutsui, K. Tominaga et al., “IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 24, pp. 13962–13966, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Yoshimoto, H. Mizutani, H. Tsutsui et al., “IL-I 8 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6,” Nature Immunology, vol. 1, no. 2, pp. 132–137, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Hoshino, R. H. Wiltrout, and H. A. Young, “IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response,” The Journal of Immunology, vol. 162, no. 9, pp. 5070–5077, 1999. View at Google Scholar · View at Scopus
  19. K. Nakanishi, T. Yoshimoto, H. Tsutsui, and H. Okamura, “Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu,” Cytokine and Growth Factor Reviews, vol. 12, no. 1, pp. 53–72, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Hoshino, H. Yagita, J. R. Ortaldo, R. H. Wiltrout, and H. A. Young, “In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells,” European Journal of Immunology, vol. 30, no. 7, pp. 1998–2006, 2000. View at Google Scholar
  21. M. G. Netea, B. J. Kullberg, I. Verschueren, and J. W. M. van der Meer, “Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1 beta,” European Journal of Immunology, vol. 30, no. 10, pp. 3057–3060, 2000. View at Publisher · View at Google Scholar
  22. C. A. Dinarello and G. Fantuzzi, “Interleukin-18 and host defense against infection,” Journal of Infectious Diseases, vol. 187, no. 2, pp. S370–S384, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Helmby and R. K. Grencis, “IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-γ during Trichinella spiralis infection,” The Journal of Immunology, vol. 169, no. 5, pp. 2553–2560, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. X.-Q. Wei, B. P. Leung, H. M. L. Arthur, I. B. McInnes, and F. Y. Liew, “Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18,” The Journal of Immunology, vol. 166, no. 1, pp. 517–521, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Akita, T. Ohtsuki, Y. Nukada et al., “Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells,” Journal of Biological Chemistry, vol. 272, no. 42, pp. 26595–26603, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Okamura, H. Tsutsui, T. Komatsu et al., “Cloning of a new cytokine that induces IFN-γ production by T cells,” Nature, vol. 378, no. 6552, pp. 88–91, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Rasouli, M. Kalani, A. Moravej, and S. Kiany, “Interleukin-18 single nucleotide polymorphisms contribute to the susceptibility to brucellosis in Iranian patients,” Cytokine, vol. 54, no. 3, pp. 272–276, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. P.-A. Zhang, J.-M. Wu, Y. Li, and X.-S. Yang, “Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population,” World Journal of Gastroenterology, vol. 11, no. 11, pp. 1594–1598, 2005. View at Google Scholar · View at Scopus
  29. N. A. C. Tavares, M. M. S. Santos, R. Moura et al., “Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients,” Cytokine, vol. 62, no. 2, pp. 286–289, 2013. View at Publisher · View at Google Scholar · View at Scopus