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The Scientific World Journal
Volume 2014, Article ID 852356, 8 pages
Review Article

PEEP Role in ICU and Operating Room: From Pathophysiology to Clinical Practice

1Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II,” 80100 Naples, Italy
2Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
3Department of Critical Care Medicine, “Città della Salute e della Scienza” Hospital, 10121 Turin, Italy
4Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy

Received 5 October 2013; Accepted 24 December 2013; Published 14 January 2014

Academic Editors: M. Elbarbary, L. M. Gillman, A. E. Papalois, and A. Shiloh

Copyright © 2014 M. Vargas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Positive end expiratory pressure (PEEP) may prevent cyclic opening and collapsing alveoli in acute respiratory distress syndrome (ARDS) patients, but it may play a role also in general anesthesia. This review is organized in two sections. The first one reports the pathophysiological effect of PEEP on thoracic pressure and hemodynamic and cerebral perfusion pressure. The second section summarizes the knowledge and evidence of the use of PEEP in general anesthesia and intensive care. More specifically, for intensive care this review refers to ARDS and traumatic brain injured patients.