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The Scientific World Journal
Volume 2014, Article ID 852507, 9 pages
http://dx.doi.org/10.1155/2014/852507
Clinical Study

Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina

1Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan
2The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, Taiwan
3Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
4Department of Pediatrics, Taipei Medical University Hospital, Taipei 11031, Taiwan
5Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan 33302, Taiwan
6Department of Cardiology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan

Received 10 December 2013; Accepted 22 January 2014; Published 5 March 2014

Academic Editors: C. Carbucicchio and H. Kitabata

Copyright © 2014 Heng-Jung Hsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1–3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.