Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina

Table 4

Univariate analysis of variables associated with coronary vasospasm in the study patients.

Variables	All patients			CKD stage 1			CKD stage 2			CKD stage 3
	𝑁=458/859			𝑁=122/230			𝑁=258/483			𝑁=78/146
	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Age, years	1.02	1.008–1.031	0.001	1.041	1.015–1.067	0.002	1.019	1.003–1.035	0.019	1.017	0.947–1.041	0.701
Men versus women	2.429	1.835–3.215	<0.001	2.431	1.778–3.324	<0.001	2.245	1.529–3.297	<0.001	2.668	1.360–5.234	0.004
Smoker (yes versus no)	2.48	1.849–3.326	<0.001	2.655	1.920–3.672	<0.001	2.355	1.595–3.475	<0.001	1.794	0.895–3.598	0.1
Peripheral white blood cell count, /1000 mm^3	1.244	1.143–1.353	<0.001	1.221	1.112–1.339	<0.001	1.21	1.087–1.347	0.001	1.356	1.098–1.675	0.005
Peripheral monocyte blood cell count, /mm^3	1.003	1.002–1.003	<0.001	1.003	1.002–1.004	<0.001	1.002	1.001–1.003	<0.001	1.002	1.001–1.004	0.007
Haemoglobin, g/dL	1.152	1.045–1.271	0.004	1.147	1.026–1.283	0.016	1.141	0.998–1.304	0.053	1.207	0.970–1.502	0.091
eGFR, mL/min/1.73 m^2	0.997	0.991–1.003	0.36	0.984	0.975–0.994	0.001	0.992	0.983–1.001	0.075	0.986	0.966–1.006	0.175
hs-CRP, mg/L	1.133	1.067–1.202	<0.001	1.15	1.070–1.236	<0.001	1.186	1.078–1.304	<0.001	1.09	0.987–1.204	0.089

Statistical significance based on binary logistic regression analysis. CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; hs-CRP: high-sensitivity C-reactive protein.