Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats

Figure 2

Effect of test compounds on FBG and OGTT in nicotinamide-STZ diabetic rats; (a) fasting blood glucose (FBG) (mg/dL); (b) OGTT; and (c) area under the curve [AUC]; G1: normal control; G2: diabetic control (nicotinamide + STZ); G3: diabetic + glibenclamide (2.5 mg/kg); G4: diabetic + quercetin (10 mg/kg); G5: diabetic + JY-1; G6: diabetic + JY-2; G7: diabetic + JY-3; G8: diabetic + JY-4; (test compounds at optimised dose of 80 mg/kg); compared to normal rats (G1); compared to diabetic rats (G2) (one-way ANOVA followed by Tukey’s post-hoc test).

(a)

(b)

(c)