Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats

<div>Effect of test compounds on serum lipids in nicotinamide-STZ rats; (a) TG, (b) TC, (c) HDL, (d) LDL, (e) VLDL (f) TC/DHL-ratio; G1: normal control; G2: diabetic control (nicotinamide + STZ); G3: diabetic + glibenclamide (2.5 mg/kg); G4: diabetic + quercetin (10 mg/kg); G5: diabetic + JY-1; G6: diabetic + JY-2; G7: Diabetic + JY-3; G8: diabetic + JY-4; (test compounds at optimised dose of 80 mg/kg); all values mean ± SEM (<svg height="8.91176pt" id="M20" style="vertical-align:-0.2130003pt" version="1.1" viewbox="-0.0498162 -8.69876 29.0065 8.91176" width="29.0065pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 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395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> compared to normal control (G1), <svg height="13.449pt" id="M22" style="vertical-align:-0.6617002pt" version="1.1" viewbox="-0.0498162 -12.7873 52.0598 13.449" width="52.0598pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0095,0,0,-0.0095,0,-5.984)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 449 249 446 233 439L152 404ZM152 374C170 384 202 393 230 393C313 393 382 326 382 213C382 97 330 26 246 26C194 26 165 62 158 81C154 91 152 101 152 116V374Z" id="g190-99"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="508" vert-adv-y="508"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,5.334,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 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id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> compared to diabetic control (G2) (one-way ANOVA followed by Tukey’s post-hoc test).</div>

The Scientific World Journal

fig3

Figure 3

Figure 3: Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats 