Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats

Figure 7

Effect of test compounds on enzymatic and nonenzymatic antioxidants and TBARS in nicotinamide, STZ diabetic rat liver; (a) glutathione (nmol/mg proteins); (b) total thiols (μmol/mg protein); (c) TBARS (nmol/g of tissue); (d) SOD (U/mg protein); and (e) catalase (U/mg proteins); (f) GST (U/mg proteins); G1: normal control; G2: diabetic control (nicotinamide + STZ); G3: diabetic + glibenclamide (2.5 mg/kg); G4: diabetic + quercetin (10 mg/kg); G5: diabetic + JY-1; G6: diabetic + JY-2; G7: diabetic + JY-3; and G8: diabetic + JY-4; (test compounds at optimised dose of 80 mg/kg); compared to normal control (G1), compared to diabetic control (G2) (one-way ANOVA followed by Tukey’s post-hoc test).

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