Review Article
Functional Stability of Plasminogen Activator Inhibitor-1
Table 1
Random mutagenesis approach to the stability of PAI-1.
| Mutation | Stability increase | | Reference |
| I91L | 9-fold | 18 h | [61] | N150H, K154T, Q319L, and M354I | 72-fold | 145 h | [125] | N150H, K154T, Q319L, M354I, and Q301P | 75-fold | 150 h | [126] | Combination of mutations at positions 50, 56, 61, 70, 94, 150, 222, 223, 264, and 331 | 122-fold | 245 h | [127] | Disulfide mutant | 350-fold | 700 h | [128] |
|
|