Effect of Fluticasone and Salmeterol on Tracheal Responsiveness to Ovalbumin and Lung Inflammation, Administrated during and after Sensitization

Figure 2

Individual values and mean ± SEM (big symbols with bars) of tracheal response to ovalbumin (OA) in control group and sensitized groups treated with fluticasone + salmeterol and placebo during (A), after (B), and during sensitization period and 18 days delay (C). Tracheal responsiveness to OA was measured by percent contraction obtained by 0.1% solution of OA compared to 10 μM methacholine. Comparisons of the data between control and three treated and three placebo groups were done using one-way analysis of variance (ANOVA) with Tukey-Kramer posttest, ⁺⁺: 𝑃<0.01, and ⁺⁺⁺: 𝑃<0.001. Comparison of the data between each treated group with fluticasone propionate + salmeterol and corresponding placebo group was done using unpaired 𝑡-test, **: 𝑃<0.01, ***: 𝑃<0.001, NS: nonsignificant.