Effect of Fluticasone and Salmeterol on Tracheal Responsiveness to Ovalbumin and Lung Inflammation, Administrated during and after Sensitization

Figure 3

Individual values and mean ± SEM (big symbols with bars) of total WBC count (count/mL) (b) in control group and sensitized groups treated with fluticasone + salmeterol and placebo during (A), after (B) and during sensitization period and 18 days delay (C). Tracheal responsiveness to OA was measured by percent contraction obtained by 0.1% solution of OA compared to 10 μM methacholine. Comparison of the data between control and three treated and three placebo groups were done using one way analysis of variance (ANOVA) with Tukey-Kramer posttest, ⁺⁺: 𝑃<0.01, and ⁺⁺⁺: 𝑃<0.001. Comparison of the data between each treated group with fluticasone propionate + salmeterol and corresponding placebo group was done using unpaired 𝑡 test, **: 𝑃<0.01, ***: 𝑃<0.001, NS: nonsignificant.