Effect of Fluticasone and Salmeterol on Tracheal Responsiveness to Ovalbumin and Lung Inflammation, Administrated during and after Sensitization

Table 1

Percent improvements in tracheal responses to OA and total and differential count of white blood cells in lung lavage changes in three treatment groups A, B, and C.

Parameters	Treatment group A	Treatment group B	Treatment group C
OVA	102.71±23.86	11.14±3.09^++	35.14±12.73^∗
Total WBC	109.42±29.15	194±20.03	233.28±33.99^∗
Eosinophil %	204.85±17.04	44.71±17.85^+++	101.42±26.13^¶¶
Neutrophil %	22.42±4.20	12.14±4.96	15.71±3.93
Monocyte %	495.42±127.90	120.42±31.25^++	155.71±25.96^∗
Lymphocyte %	59.28±9.31	20.71±3.22^++	20.71±9.33^∗∗

Values are quoted as mean ± SEM. Percent improvements were achieved as follows. In cases, the treatment data was greater than that of corresponding placebo; the data obtained in treatment group minus the data obtained in corresponding placebo group was divided by the data obtained in the same placebo group and multiplied by 100 (e.g. [(Treatment_A1 − Placebo_A1)/Placebo_A1]100). In cases, the treatment data was lower than that of corresponding placebo; the data obtained in placebo group minus the data obtained in corresponding treatment group was divided by the data obtained in the same treatment group and multiplied by 100 (e.g. [(Placebo_A1 − Treatment_A1)/Treatment_A1]100). Comparisons of the data between three treatment groups were done using one-way analysis of variance (ANOVA) with Tukey-Kramer posttest.
Statistical significance for the difference between the data of group A versus group B: ⁺⁺𝑃<0.01, ⁺⁺⁺𝑃<0.001.
Statistical significance for the difference between the data of group A versus group C: *𝑃<0.5, **𝑃<0.01.
Statistical significance for the difference between the data of group B versus group C: ^¶¶𝑃<0.01.