Update on Intra-Arterial Chemotherapy for Retinoblastoma

Table 1

The International Classification of Retinoblastoma (IRCB) [7].

Group	Defining features
A	Tumor <3 mm in size
B	Tumor >3 mm in size or macular Rb location; juxtapapillary Rb location, clear subretinal fluid ≤3 mm from margin
C	Tumor with focal seeding: subretinal seeds ≤3 mm from Rb; vitreous seeds ≤3 mm from Rb; subretinal and vitreous seeds ≤3 mm from Rb
D	Tumor with diffuse seeding: subretinal seeds >3 mm from Rb; vitreous seeds >3 mm from Rb; subretinal and vitreous seeds >3 mm from Rb
E	Extensive tumor occupying >50% of the globe or neovascular glaucoma; invasion of postlaminar optic nerve, choroid, sclera, orbit, anterior chamber; massive intraocular hemorrhage

^∗Rb: retinoblastoma.