4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells
Figure 4
4-HNE inhibits AKT pathways in MG63 cells. (a)-(b) Western blots (a) and histograms (b) showing the decreasing of protein levels of pAKT by 4-HNE treatment (5 to 50 μM, and 2 h to 4 h) in MG63 cells. Results are averages of three independent experiments. (c)-(d) Western blots (a) and histograms (b) showing the decreasing of protein levels of pp70S6K by 4-HNE treatment (5 to 50 μM, and 2 h to 4 h) in MG63 cells. Results are averages of three independent experiments.
