4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells

<table>Models. Simplified scheme showed that 4-HNE could inactivate AKT activity, alter the ratio of BcL-2/Bax, induce caspase-3 cascades, and finally lead to apoptosis in MG63 cells.</table>

The Scientific World Journal

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Figure 5

Figure 5: 4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells 