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The Scientific World Journal
Volume 2014 (2014), Article ID 876363, 9 pages
http://dx.doi.org/10.1155/2014/876363
Research Article

HIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes

1Surgical Department of Cervical Spine, The Second Affiliated Hospital of Inner Mongolia Medical University, 1 Yingfang Dao Hohehot, Mongolia 010030, China
2Medical School of Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China

Received 28 November 2013; Accepted 24 December 2013; Published 25 March 2014

Academic Editors: H. Okamura and Y. Xi

Copyright © 2014 Zhiqiang Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Fang-Jie Zhang, Wei Luo, and Guang-Hua Lei, “Role of HIF-1α and HIF-2α in osteoarthritis,” Joint Bone Spine, 2014. View at Publisher · View at Google Scholar
  • Emily C. Lynam, Yan Xie, Rebecca Dawson, Jacqui Mcgovern, Zee Upton, and XiQiao Wang, “Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis,” Wound Repair And Regeneration, vol. 23, no. 5, pp. 664–671, 2015. View at Publisher · View at Google Scholar
  • Fang-Jie Zhang, Wei Luo, and Guang-Hua Lei, “Role of HIF-1α And HIF-2α In osteoarthritis,” Joint Bone Spine, vol. 82, no. 3, pp. 144–147, 2015. View at Publisher · View at Google Scholar
  • Zhiqiang Chang, Lifeng Huo, Pengfei Li, Yimin Wu, and Pei Zhang, “Ascorbic acid provides protection for human chondrocytes against oxidative stress,” Molecular Medicine Reports, vol. 12, no. 5, pp. 7086–7092, 2015. View at Publisher · View at Google Scholar
  • Eel Zhang, Jing Wang, Jianjun Chu, Cheng Yang, Hui Xiao, Chenglong Zhao, Zhengwang Sun, Xin Gao, Guanghui Chen, Zhitao Han, Weiwei Zou, and Tielong Liu, “MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through BcI-2,” Cellular Physiology And Biochemistry, vol. 37, no. 4, pp. 1442–1453, 2015. View at Publisher · View at Google Scholar
  • Qiu, Zeng, Zhou, Yang, Chen, and Guo, “Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction,” Genetics and Molecular Research, vol. 15, no. 2, 2016. View at Publisher · View at Google Scholar
  • Zhifu Li, Dongdong Meng, Guangheng Li, Jianzhong Xu, Ke Tian, and Yu Li, “Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3 alpha in osteoarthritis,” Molecular Medicine Reports, vol. 13, no. 3, pp. 2769–2776, 2016. View at Publisher · View at Google Scholar
  • Jun Yin, Bing Ni, Wei-Gong Liao, and Yu-Qi Gao, “Hypoxia-induced apoptosis of mouse spermatocytes is mediated by HIF-1α through a death receptor pathway and a mitochondrial pathway,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar
  • Jin, Chen, Gao, Liu, Hou, and Zheng, “The role of miR-320a and IL-1β in human chondrocyte degradation,” Bone and Joint Research, vol. 6, no. 4, pp. 196–203, 2017. View at Publisher · View at Google Scholar
  • Kai Zhang, and Dianming Jiang, “RhoA inhibits the hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes via positively regulating the CREB phosphorylation,” Bioscience Reports, vol. 37, no. 2, 2017. View at Publisher · View at Google Scholar