HIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes
Figure 5
Downexpression of miR-210 increased apoptosis via HIF-1α in hypoxic C28/I2 cells. Apoptosis of C28/I2 cells transfected with miR-210 mimics, miR-anti, or HIF-1α si was measured by flow cytometry after 48 h upon hypoxia or normoxia. (a) Apoptotic rate in C28/I2 cells on normoxia. (b) Apoptotic rate in hypoxic C28/I2 cells. Three individual experiments were conducted. The significant differences were denoted as *.
