Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain

Figure 7

Step-down electronic inhibitory avoidance task. ^∗𝑃<0.05, ^#𝑃<0.05 versus Con. group, ^△𝑃<0.05 versus DM group. (a) The error time before modeling. The error time reached the similar time level after the rats were trained for 4 d. ^∗∗𝑃<0.01, ^##𝑃<0.01 versus 1 d. (b) The latency before modeling. The latency was increased after the rats were trained for 3 d and 4 d. ^∗∗𝑃<0.01, ^##𝑃<0.01 versus 4 d. (c) The error time at 10 days after LiCl administration. The error time increased in DM group but decreased in group with LiCl administration for 10 days. ^∗𝑃<0.05, ^#𝑃<0.05 versus Con. group, ^△𝑃<0.05 versus DM group. (d) The latency at 10 days after LiCl administration. The latency decreased in DM group but increased in group treated with LiCl administration for 10 days. ^∗𝑃<0.05, ^#𝑃<0.05 versus Con, ^△𝑃<0.05 versus DM.

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