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The Scientific World Journal
Volume 2014, Article ID 879405, 6 pages
http://dx.doi.org/10.1155/2014/879405
Research Article

Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus

Department of Zoology, Punjab Agricultural University, Ludhiana 141004, India

Received 8 July 2014; Accepted 8 September 2014; Published 13 October 2014

Academic Editor: Bay Boon Huat

Copyright © 2014 Neena Singla and Swati Challana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus.