Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals
Table 1
Effect of methanolic extract of fruit of Bridelia retusa on carrageenan-induced paw oedema.
Treatment
Dose (mg/kg b.w.)
Increase in paw circumference (cm)
Control
3.32 ± 0.05
3.78 ± 0.03
4.23 ± 0.06
4.42 ± 0.08
4.49 ± 0.06
Indomethacin
10
2.86 ± 0.03*** (49.27)
3.02 ± 0.06*** (55.65)
3.15 ± 0.05*** (60)
3.21 ± 0.06*** (60.89)
3.18 ± 0.04*** (63.98)
BRME
100
3.19 ± 0.05 (−1.45)
3.61 ± 0.06 (2.61)
4.03 ± 0.02 (3.75)
4.21 ± 0.03* (3.91)
4.27 ± 2.63* (4.3)
BRME
200
3.23 ± 0.03 (20.29)
3.56 ± 0.04* (23.48)
3.89 ± 0.05*** (24.38)
4.02 ± 0.07*** (25.15)
3.93 ± 0.06*** (32.8)
BRME
400
3.08 ± 0.04* (23.19)
3.37 ± 0.08*** (28.7)
3.59 ± 0.06*** (35)
3.66 ± 0.03*** (38.13)
3.62 ± 0.04*** (42.5)
Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development. . (two-way ANOVA followed by Bonferroni’s test).
