Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals

Table 2

Effect of methanolic extract of fruit of Bridelia retusa on histamine-induced paw oedema.

Treatment	Dose (mg/kg b.w.)	Thickness of rat paw (cm)
		Control		2.64 ± 0.04	3.13 ± 0.05	3.64 ± 0.07	3.86 ± 0.06	3.98 ± 0.09
Indomethacin	10	2.31 ± 0.06^**; (43.75)	2.47 ± 0.07^***; (58.02)	2.53 ± 0.05^***; (69.69)	2.57 ± 0.07^***; (71.42)	2.59 ± 0.08^***; (72.28)
BRME	100	2.59 ± 0.06; (3.13)	3.04 ± 0.06; (6.17)	3.39 ± 0.08^*; (15.9)	3.52 ± 0.07^**; (19.48)	3.58 ± 0.08^***; (21.68)
BRME	200	2.57 ± 0.05; (9.38)	2.91 ± 0.04^*; (22.22)	3.11 ± 0.07^**; (37.12)	3.18 ± 0.09^***; (41.56)	3.21 ± 0.09^***; (43.98)
BRME	400	2.41 ± 0.05; (12.5)	2.73 ± 0.07^*; (25.93)	2.91 ± 0.07^***; (40.9)	2.97 ± 0.09^***; (45.45)	3.01 ± 0.05^***; (46.99)

Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development.
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(two-way ANOVA followed by Bonferroni’s test).