Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals
Table 3
Effect of methanolic extract of fruit of Bridelia retusa on serotonin-induced paw oedema.
Treatment
Dose (mg/kg b.w.)
Thickness of rat paw (cm)
Control
3.21 ± 0.03
3.64 ± 0.04
3.95 ± 0.02
4.11 ± 0.03
4.06 ± 0.06
Indomethacin
10
2.97 ± 0.04*** (45.71)
3.06 ± 0.06*** (64.1)
3.11 ± 0.03*** (69.72)
3.14 ± 0.05*** (71.2)
3.09 ± 0.04*** (74.17)
BRME
100
3.07 ± 0.06 (11.42)
3.42 ± 0.03* (15.39)
3.57 ± 0.05** (25.69)
3.66 ± 0.03*** (28)
3.59 ± 0.06*** (30.83)
BRME
200
3.08 ± 0.05 (14.29)
3.28 ± 0.02** (35.9)
3.37 ± 0.03*** (45.87)
3.46 ± 0.04*** (45.6)
3.39 ± 0.05*** (49.17)
BRME
400
3.12 ± 0.04 (17.14)
3.29 ± 0.02*** (41.02)
3.41 ± 0.05*** (46.79)
3.46 ± 0.04*** (49.6)
3.39 ± 0.03*** (53.33)
Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development. . . (two-way ANOVA followed by Bonferroni’s test).
