Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals

Table 4

Effect of methanolic extract of fruit of Bridelia retusa on arachidonic acid-induced paw oedema.

Treatment	Dose (mg/kg b.w.)	Thickness of rat paw (cm)
		Control		2.76 ± 0.06	3.18 ± 0.07	3.57 ± 0.08	3.71 ± 0.06	3.59 ± 0.09
Indomethacin	10	2.02 ± 0.09^***; (73.44)	2.11 ± 0.08^***; (75.47)	2.18 ± 0.06^***; (77.24)	2.22 ± 0.07^***; (76.73)	2.16 ± 0.08^***; (78.91)
BRME	100	2.51 ± 0.06; (1.56)	2.88 ± 0.04; (5.66)	3.02 ± 0.06^*; (21.38)	3.11 ± 0.08^***; (22.64)	3.07 ± 0.09^***; (19.04)
BRME	200	2.46 ± 0.06^*; (10.94)	2.67 ± 0.07^***; (26.41)	2.84 ± 0.04^***; (34.48)	2.91 ± 0.08^***; (35.85)	2.87 ± 0.09^***; (33.33)
BRME	400	2.43 ± 0.08^**; (12.5)	2.64 ± 0.08^***; (27.36)	2.73 ± 0.07^***; (40.69)	2.77 ± 0.09^***; (43.4)	2.71 ± 0.05^***; (42.86)

Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development.
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(two-way ANOVA followed by Bonferroni’s test).