Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals

Table 5

Effect of methanolic extract of fruit of Bridelia retusa on formalin-induced paw oedema.

Treatment	Dose (mg/kg b.w.)	Thickness of rat paw (cm)
		Day 1	Day 2	Day 3	Day 4	Day 5	Day 6
Control		1.86 ± 0.15	2.12 ± 0.14	2.54 ± 0.12	2.78 ± 0.16	2.94 ± 0.17	3.13 ± 0.18
Indomethacin	10	1.37 ± 0.09^*; (43.49)	1.43 ± 0.08^***; (62.32)	1.54 ± 0.12^***; (66.67)	1.56 ± 0.15^***; (71.12)	1.58 ± 0.13^***; (72.85)	1.55 ± 0.14^***; (77.65)
BRME	100	1.67 ± 0.09; (4.65)	1.85 ± 0.12; (7.25)	2.21 ± 0.16; (9.9)	2.37 ± 0.13; (14.07)	2.46 ± 0.17^*; (17.22)	2.68 ± 0.12^***; (13.53)
BRME	200	1.54 ± 0.09; (6.98)	1.72 ± 0.06; (15.94)	1.98 ± 0.15^**; (24.32)	2.13 ± 0.11^**; (26.67)	2.24 ± 0.12^***; (27.15)	2.39 ± 0.14^***; (26.47)
BRME	400	1.52 ± 0.09; (20.93)	1.61 ± 0.1^*; (37.68)	1.79 ± 0.13^***; (45.04)	1.88 ± 0.11^***; (48.04)	1.97 ± 0.12^***; (47.68)	2.06 ± 0.12^***; (48.34)

Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development.
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(two-way ANOVA followed by Bonferroni’s test).