Antinociceptive and Anti-Inflammatory Activities of Bridelia retusa Methanolic Fruit Extract in Experimental Animals
Table 5
Effect of methanolic extract of fruit of Bridelia retusa on formalin-induced paw oedema.
Treatment
Dose (mg/kg b.w.)
Thickness of rat paw (cm)
Day 1
Day 2
Day 3
Day 4
Day 5
Day 6
Control
1.86 ± 0.15
2.12 ± 0.14
2.54 ± 0.12
2.78 ± 0.16
2.94 ± 0.17
3.13 ± 0.18
Indomethacin
10
1.37 ± 0.09* (43.49)
1.43 ± 0.08*** (62.32)
1.54 ± 0.12*** (66.67)
1.56 ± 0.15*** (71.12)
1.58 ± 0.13*** (72.85)
1.55 ± 0.14*** (77.65)
BRME
100
1.67 ± 0.09 (4.65)
1.85 ± 0.12 (7.25)
2.21 ± 0.16 (9.9)
2.37 ± 0.13 (14.07)
2.46 ± 0.17* (17.22)
2.68 ± 0.12*** (13.53)
BRME
200
1.54 ± 0.09 (6.98)
1.72 ± 0.06 (15.94)
1.98 ± 0.15** (24.32)
2.13 ± 0.11** (26.67)
2.24 ± 0.12*** (27.15)
2.39 ± 0.14*** (26.47)
BRME
400
1.52 ± 0.09 (20.93)
1.61 ± 0.1* (37.68)
1.79 ± 0.13*** (45.04)
1.88 ± 0.11*** (48.04)
1.97 ± 0.12*** (47.68)
2.06 ± 0.12*** (48.34)
Values are expressed as means ± SEM (). Figures in parenthesis indicate percentage inhibition of oedema development. . . (two-way ANOVA followed by Bonferroni’s test).