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The Scientific World Journal
Volume 2014, Article ID 895839, 6 pages
http://dx.doi.org/10.1155/2014/895839
Review Article

Low Molecular Weight Heparin in Portal Vein Thrombosis of Cirrhotic Patients: Only Therapeutic Purposes?

Gastroenterology Section, Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, Azienda Universitario-Ospedaliera Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy

Received 28 July 2014; Revised 3 December 2014; Accepted 11 December 2014; Published 29 December 2014

Academic Editor: Tomasz Brzozowski

Copyright © 2014 Raffaele Licinio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Schuppan and N. H. Afdhal, “Liver cirrhosis,” The Lancet, vol. 371, no. 9615, pp. 838–851, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Garcia-Tsao, R. J. Groszmann, R. L. Fisher, H. O. Conn, C. E. Atterbury, and M. Glickman, “Portal pressure, presence of gastroesophageal varices and variceal bleeding,” Hepatology, vol. 5, no. 3, pp. 419–424, 1985. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Primignani, “Portal vein thrombosis, revisited,” Digestive and Liver Disease, vol. 42, no. 3, pp. 163–170, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. K. Søgaard, E. Horváth-Puhó, H. Grønbæk, P. Jepsen, H. Vilstrup, and H. T. Sørensen, “Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study,” The American Journal of Gastroenterology, vol. 104, no. 1, pp. 96–101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. N. M. Intagliata, Z. H. Henry, N. Shah, T. Lisman, S. H. Caldwell, and P. G. Northup, “Prophylactic anticoagulation for venous thromboembolism in hospitalized cirrhosis patients is not associated with high rates of gastrointestinal bleeding,” Liver International, vol. 34, no. 1, pp. 26–32, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Tripodi, M. Primignani, V. Chantarangkul et al., “An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis,” Gastroenterology, vol. 137, no. 6, pp. 2105–2111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Tripodi and P. M. Mannucci, “The coagulopathy of chronic liver disease,” The New England Journal of Medicine, vol. 365, no. 2, pp. 147–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Ventura, M. C. Rosa, G. Abbati et al., “Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics,” Liver International, vol. 25, no. 1, pp. 49–56, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Ferro, S. Basili, A. Lattuada et al., “Systemic clotting activation by low-grade endotoxaemia in liver cirrhosis: a potential role for endothelial procoagulant activation,” Italian Journal of Gastroenterology and Hepatology, vol. 29, no. 5, pp. 434–440, 1997. View at Google Scholar · View at Scopus
  10. L. Amitrano, M. A. Guardascione, V. Brancaccio et al., “Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis,” Journal of Hepatology, vol. 40, no. 5, pp. 736–741, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Wright, R. Goldin, S. Hellier et al., “Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection,” Gut, vol. 52, no. 8, pp. 1206–1210, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. O. M. E. Abdel-Salam, A. R. Baiuomy, A. Ameen, and N. S. Hassan, “A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat,” Pharmacological Research, vol. 51, no. 1, pp. 59–67, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. F. R. Ponziani, V. De Stefano, and A. Gasbarrini, “Viral cirrhosis: an overview of haemostatic alterations and clinical consequences,” Mediterranean Journal of Hematology and Infectious Diseases, vol. 1, no. 3, Article ID e2009033, 2009. View at Google Scholar
  14. K. Borensztajn, J. Stiekema, S. Nijmeijer, P. H. Reitsma, M. P. Peppelenbosch, and C. A. Spek, “Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation,” The American Journal of Pathology, vol. 172, no. 2, pp. 309–320, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Tripodi, M. Primignani, and P. M. Mannucci, “Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged,” Internal and Emergency Medicine, vol. 5, no. 1, pp. 7–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Tripodi, S. H. Caldwell, M. Hoffman, J. F. Trotter, and A. J. Sanyal, “Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 2, pp. 141–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Kravetz, E. Sikuler, and R. J. Groszmann, “Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution,” Gastroenterology, vol. 90, pp. 1232–1240, 1986. View at Google Scholar · View at Scopus
  18. B. Castañeda, J. Morales, R. Lionetti et al., “Effects of blood volume restitution following a portal hypertensive-related bleeding in anesthetized cirrhotic rats,” Hepatology, vol. 33, no. 4, pp. 821–825, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Zocco, E. di Stasio, R. de Cristofaro et al., “Thrombotic risk factors in patients with liver cirrhosis: correlation with MELD scoring system and portal vein thrombosis development,” Journal of Hepatology, vol. 51, no. 4, pp. 682–689, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. V. La Mura, J. C. Reverter, A. Flores-Arroyo et al., “Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension,” Gut, vol. 60, no. 8, pp. 1133–1138, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Hoekstra and H. L. Janssen, “Vascular liver disorders (II): portal vein thrombosis,” Netherlands Journal of Medicine, vol. 67, no. 2, pp. 46–53, 2009. View at Google Scholar · View at Scopus
  22. F. R. Ponziani, M. A. Zocco, C. Campanale et al., “Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment,” World Journal of Gastroenterology, vol. 16, no. 2, pp. 143–155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. G. D'Amico and R. de Franchis, “Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators,” Hepatology, vol. 38, no. 3, pp. 599–612, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Noronha Ferreira, T. Rodrigues, P. Alexandrino et al., “Portal vein thrombosis in cirrhotic patients is associated with advanced liver disease and predicts poor long term prognosis,” in Proceedings of the Liver Meeting, AASLD, 2010.
  25. M. J. Englesbe, D. E. Schaubel, S. Cai, M. K. Guidinger, and R. M. Merion, “Portal vein thrombosis and liver transplant survival benefit,” Liver Transplantation, vol. 16, no. 8, pp. 999–1005, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Maruyama, H. Okugawa, M. Takahashi, and O. Yokosuka, “De novo portal vein thrombosis in virus-related cirrhosis: predictive factors and long-term outcomes,” The American Journal of Gastroenterology, vol. 108, no. 4, pp. 568–574, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. L. D. DeLeve, D.-C. Valla, and G. Garcia-Tsao, “Vascular disorders of the liver,” Hepatology, vol. 49, no. 5, pp. 1729–1764, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. M. Bates and J. S. Ginsberg, “Clinical practice. Treatment of deep-vein thrombosis,” The New England Journal of Medicine, vol. 351, no. 3, pp. 268–277, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Condat, F. Pessione, M. Helene Denninger, S. Hillaire, and D. Valla, “Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy,” Hepatology, vol. 32, no. 3, pp. 466–470, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Plessier, S. Darwish-Murad, M. Hernandez-Guerra et al., “Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study,” Hepatology, vol. 51, no. 1, pp. 210–218, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Senzolo, T. M. Sartori, V. Rossetto et al., “Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis,” Liver International, vol. 32, no. 6, pp. 919–927, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. K. T. Werner, S. Sando, E. J. Carey et al., “Portal vein thrombosis in patients with end stage liver disease awaiting liver transplantation: outcome of anticoagulation,” Digestive Diseases and Sciences, vol. 58, no. 6, pp. 1776–1780, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Silva-Junior, F. Turon, V. Hernandez-Gea et al., “Unexpected disappearance of portal cavernoma in long-term anticoagulation,” Journal of Hepatology, vol. 61, no. 2, pp. 446–448, 2014. View at Publisher · View at Google Scholar
  34. M. G. Delgado, S. Seijo, I. Yepes et al., “Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis,” Clinical Gastroenterology and Hepatology, vol. 10, no. 7, pp. 776–783, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Amitrano, M. A. Guardascione, A. Menchise et al., “Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis,” Journal of Clinical Gastroenterology, vol. 44, no. 6, pp. 448–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Francoz, J. Belghiti, V. Vilgrain et al., “Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation,” Gut, vol. 54, no. 5, pp. 691–697, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Hirsh, K. A. Bauer, M. B. Donati et al., “Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition),” Chest, vol. 133, supplement 6, pp. 141S–159S, 2008. View at Publisher · View at Google Scholar
  38. R. L. Bick, E. P. Frenkel, J. Walenga, J. Fareed, and D. A. Hoppensteadt, “Unfractionated heparin, low molecular weight heparins, and pentasaccharide: basic mechanism of actions, pharmacology, and clinical use,” Hematology/Oncology Clinics of North America, vol. 19, no. 1, pp. 1–51, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. V. Laux, E. Perzborn, S. Heitmeier et al., “Direct inhibitors of coagulation proteins—the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy?” Thrombosis and Haemostasis, vol. 102, no. 5, pp. 892–899, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. E. Villa, C. Cammà, M. Marietta et al., “Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis,” Gastroenterology, vol. 143, no. 5, pp. 1253–1260, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Lisman and R. J. Porte, “Towards a rational use of low-molecular-weight heparin in patients with cirrhosis,” Liver International, vol. 31, no. 7, p. 1063, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. M. J. García-Fuster, N. Abdilla, M. J. Fabiá, C. Fernández, V. Oliver, and M. J. Forner, “Venous thromboembolism and liver cirrhosis,” Revista Espanola de Enfermedades Digestivas, vol. 100, no. 5, pp. 259–262, 2008. View at Google Scholar · View at Scopus
  43. C. Francoz, D. Valla, and F. Durand, “Portal vein thrombosis, cirrhosis, and liver transplantation,” Journal of Hepatology, vol. 57, no. 1, pp. 203–212, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. C. S. Landefeld, E. F. Cook, M. Flatley, M. Weisberg, and L. Goldman, “Identification and preliminary validation of predictors of major bleeding in hospitalized patients starting anticoagulant therapy,” American Journal of Medicine, vol. 82, no. 4, pp. 703–713, 1987. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Shi, J.-H. Hao, W.-H. Ren, and J.-R. Zhu, “Effects of heparin on liver fibrosis in patients with chronic hepatitis B,” World Journal of Gastroenterology, vol. 9, no. 7, pp. 1611–1614, 2003. View at Google Scholar · View at Scopus
  46. S. Fagiuali, V. G. Mirante, and M. Pompili, “Monotematica AISF 2000-OLT study group. Liver transplantation: the Italian experience,” Digestive and Liver Disease, vol. 34, no. 9, pp. 640–648, 2002. View at Publisher · View at Google Scholar