Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 896206, 6 pages
http://dx.doi.org/10.1155/2014/896206
Review Article

Competing Endogenous RNA: The Key to Posttranscriptional Regulation

1Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, India
2Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India

Received 22 August 2013; Accepted 10 December 2013; Published 2 February 2014

Academic Editors: C. Lecoeur, C. Y. Liu, and A. C. Manna

Copyright © 2014 Rituparno Sen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [64 citations]

The following is the list of published articles that have cited the current article.

  • Gianna Carvalheira, Mariana Moysés Oliveira, Sylvia Takeno, Fernanda Teresa de Lima, Vera Ayres Meloni, and Maria Isabel Melaragno, “19q13.33→qter trisomy in a girl with intellectual impairment and seizures,” Meta Gene, vol. 2, pp. 799–806, 2014. View at Publisher · View at Google Scholar
  • Linjiang Pan, Suning Huang, Rongquan He, Minhua Rong, Yiwu Dang, and Gang Chen, “Decreased expression and clinical significance of miR-148a in hepatocellular carcinoma tissues,” European Journal of Medical Research, vol. 19, no. 1, 2014. View at Publisher · View at Google Scholar
  • Dale Cowley, Kumar Pandya, Israr Khan, John Kerwin, Kate Owen, and Erin Griner, “Registered report: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology,” eLife, vol. 4, 2015. View at Publisher · View at Google Scholar
  • Weizhao Peng, Shuang Si, Qingxia Zhang, Chaofeng Li, Fang Zhao, Fang Wang, Jia Yu, and Ren Ma, “Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression,” Journal Of Experimental & Clinical Cancer Research, vol. 34, 2015. View at Publisher · View at Google Scholar
  • Jiemei Tan, Kaifeng Qiu, Mingyi Li, and Ying Liang, “Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells,” FEBS Letters, 2015. View at Publisher · View at Google Scholar
  • Chao He, Jia-Wang Ding, Song Li, Hui Wu, Yu-Rong Jiang, Wei Yang, Lin Teng, Jun Yang, and Jian Yang, “The Role of Long Intergenic Noncoding RNA p21 in Vascular Endothelial Cells,” DNA and Cell Biology, pp. 150814092733002, 2015. View at Publisher · View at Google Scholar
  • Dong Lan, Xin Zhang, Rongquan He, Ruixue Tang, Ping Li, Qiancheng He, and Gang Chen, “MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance,” European Journal of Medical Research, vol. 20, no. 1, 2015. View at Publisher · View at Google Scholar
  • Sercan Ergun, and Serdar Oztuzcu, “Oncocers: ceRNA-mediated cross-talk by sponging miRNAs in oncogenic pathways,” Tumor Biology, 2015. View at Publisher · View at Google Scholar
  • Jing Xie, Bomin Guo, Zheng Ding, Jie Kang, Xianzhao Deng, Bo Wu, and Youben Fan, “Microarray Analysis of IncRNAs and mRNAs Co-Expression Network and IncRNA Function as ceRNA in Papillary Thyroid Carcinoma,” Journal Of Biomaterials And Tissue Engineering, vol. 5, no. 11, pp. 872–880, 2015. View at Publisher · View at Google Scholar
  • Kaiyuan Deng, Hao Wang, Xiaoqiang Guo, and Jiazeng Xia, “The cross talk between long, non-coding RNAs and microRNAs in gastric cancer,” Acta Biochimica et Biophysica Sinica, pp. gmv120, 2015. View at Publisher · View at Google Scholar
  • Hui-Jin Li, Xu Li, Huan Pang, Jing-Jing Pan, Xiao-Juan Xie, and Wei Chen, “Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer,” Japanese Journal Of Clinical Oncology, vol. 45, no. 11, pp. 1055–1063, 2015. View at Publisher · View at Google Scholar
  • Konstantina Katsarou, A. L. N. Rao, Mina Tsagris, and Kriton Kalantidis, “Infectious long non-coding RNAs,” Biochimie, vol. 117, pp. 37–47, 2015. View at Publisher · View at Google Scholar
  • Chaoqun Huang, Ye Yang, and Lin Liu, “Interaction of long noncoding RNAs and microRNAs in the pathogenesis of idiopathic pulmonary fibrosis,” Physiological Genomics, vol. 47, no. 10, pp. 463–469, 2015. View at Publisher · View at Google Scholar
  • Laura Poliseno, and Pier Paolo Pandolfi, “PTEN ceRNA networks in human cancer,” Methods, 2015. View at Publisher · View at Google Scholar
  • Stephanie Bollmann, Jiaqi Wang, Massimo Bionaz, and Dengpan Bu, “Unmasking Upstream Gene Expression Regulators with miRNA-corrected mRNA Data,” Bioinformatics and Biology Insights, vol. 9, pp. 33–48, 2015. View at Publisher · View at Google Scholar
  • Lin-Jiang Pan, Teng-Fei Zhong, Rui-Xue Tang, Ping Li, Yi-Wu Dang, Su-Ning Huang, and Gang Chen, “Upregulation and clinicopathological significance of long non-coding NEAT1 RNA in NSCLC tissues,” Asian Pacific Journal of Cancer Prevention, vol. 16, no. 7, pp. 2851–2855, 2015. View at Publisher · View at Google Scholar
  • Walter Arancio, Valeria Carina, Giuseppe Pizzolanti, Laura Tomasello, Maria Pitrone, Concetta Baiamonte, Marco Calogero Amato, and Carla Giordano, “ Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2 , TP53 , and microRNA Biogenesis ,” International Journal of Endocrinology, vol. 2015, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Alessandro Lagana, and Alessandro Lagana, “Computational Prediction of microRNA Targets,” Microrna: Basic Science: From Molecular Biology To Clinical Practice, vol. 887, pp. 231–252, 2015. View at Publisher · View at Google Scholar
  • Lian-Ju Li, Qing Huang, Hai-Feng Pan, and Dong-Qing Ye, “Circular RNAs and systemic lupus erythematosus,” Experimental Cell Research, 2016. View at Publisher · View at Google Scholar
  • Yaojing Yue, Tingting Guo, Chao Yuan, Jianbin Liu, Ruilin Feng, Chune Niu, Jian Guo, Xiaoping Sun, and Bohui Yang, “Integrated analysis of the roles of long noncoding RNA and coding RNA expression in sheep (Ovis aries) skin during initiation of secondary hair follicle,” PLoS ONE, vol. 11, no. 6, 2016. View at Publisher · View at Google Scholar
  • Chun-Chun Ma, Zhang Xiong, Guan-Nan Zhu, Chao Wang, Gang Zong, Hong-Liang Wang, Er-Bao Bian, and Bing Zhao, “Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a,” Journal Of Experimental & Clinical Cancer Research, vol. 35, 2016. View at Publisher · View at Google Scholar
  • M. V. Shepelev, S. V. Kalinichenko, P. N. Vikhreva, and I. V. Korobko, “Selection of microRNA for providing tumor specificity of transgene expression in cancer gene therapy,” Molecular Biology, vol. 50, no. 2, pp. 284–291, 2016. View at Publisher · View at Google Scholar
  • Devyani Samantarrai, Mousumi Sahu, Garima Singh, Jyoti Roy, Chandra Bhushan, and Bibekanand Mallick, “Modern Technologies and Approaches for Decoding Non-Coding Rna-Mediated Biological Networks in Systems Biology and Their Applications,” Computational Biology and Bioinformatics, pp. 106–132, 2016. View at Publisher · View at Google Scholar
  • Mitch Phelps, Chris Coss, Hongyan Wang, and Matthew Cook, “Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs,” eLife, vol. 5, 2016. View at Publisher · View at Google Scholar
  • Rebecca Elise Barnett, Daniel J. Conklin, Lindsey Ryan, Robert C. Keskey, Vikram Ramjee, Ernesto A. Sepulveda, Sanjay Srivastava, Aruni Bhatnagar, and William G. Cheadle, “Anti-inflammatory effects of miR-21 in the macrophage response to peritonitis,” Journal Of Leukocyte Biology, vol. 99, no. 2, pp. 361–371, 2016. View at Publisher · View at Google Scholar
  • Chen Chen, Yang-yang Fan, Xin Wang, Fei Song, Tao Jiang, Ping Qian, Shun-ming Tang, and Xing-jia Shen, “bmo-miR-0001 and bmo-miR-0015 down-regulate expression of Bombyx mori fibroin light chain gene in vitro,” Journal of Zhejiang University SCIENCE B, vol. 17, no. 2, pp. 127–135, 2016. View at Publisher · View at Google Scholar
  • Chunhui Yuan, Xianwen Meng, Xue Li, Nicola Illing, Robert A. Ingle, Jingjing Wang, and Ming Chen, “PceRBase: a database of plant competing endogenous RNA,” Nucleic Acids Research, vol. 45, no. D1, pp. D1009–D1014, 2016. View at Publisher · View at Google Scholar
  • Wenkang Luan, Bin Xu, Henry Siaw Djangmah, Xiaohui Liu, Yongping You, Lubo Li, Yan Shi, Xuefeng Bu, Yun Xia, and Jinlong Wang, “Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22,” Oncotarget, vol. 7, no. 39, pp. 63901–63912, 2016. View at Publisher · View at Google Scholar
  • Tao Liu, Zheng-Lu Wang, Zhong-Yang Shen, Cai-Hua Zu, Shu-Sen Wang, Hong-Li Song, Xin-Nv Xu, Hong-Sheng Liu, and Yu-Liang Wang, “PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells,” Oncotarget, vol. 7, no. 28, pp. 43376–43389, 2016. View at Publisher · View at Google Scholar
  • Yunhu Yu, Fang Cao, Qishan Ran, and Fei Wang, “Long non-coding RNA Gm4419 promotes trauma-induced astrocyte apoptosis by targeting tumor necrosis factor α,” Biochemical and Biophysical Research Communications, 2017. View at Publisher · View at Google Scholar
  • Ming Cheng, Shoukuan An, and Junquan Li, “CDKN2B - AS may indirectly regulate coronary artery disease-associated genes via targeting miR - 92a targeting,” Gene, 2017. View at Publisher · View at Google Scholar
  • Lisha Chen, Hongbing Yao, Kai Wang, and Xiangfeng Liu, “Long Non-Coding RNA MALAT1 Regulates ZEB1 Expression by Sponging miR-143-3p and Promotes Hepatocellular Carcinoma Progression,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Zhan-Po Yang, Hong-Shun Ma, Shu-Sen Wang, Le Wang, and Tao Liu, “LAMC1 mRNA promotes malignancy of hepatocellular carcinoma cells by competing for MicroRNA-124 binding with CD151,” IUBMB Life, 2017. View at Publisher · View at Google Scholar
  • Qian Liu, Hui Liu, Hepeng Cheng, Yang Li, Xiaodong Li, and Chaoyang Zhu, “Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells,” OncoTargets and Therapy, vol. 10, pp. 2461–2471, 2017. View at Publisher · View at Google Scholar
  • Yan Yan, Qingxia Fan, Liping Wang, Yue Zhou, Jianhua Li, and Kun Zhou, “LncRNA Snhg1, a non-degradable sponge for miR-338, promotes expression of proto-oncogene CST3 in primary esophageal cancer cells.,” Oncotarget, vol. 8, no. 22, pp. 35750–35760, 2017. View at Publisher · View at Google Scholar
  • Weiwei Liu, and Chan Ding, “Roles of LncRNAs in Viral Infections,” Frontiers in Cellular and Infection Microbiology, vol. 7, 2017. View at Publisher · View at Google Scholar
  • Jiwen Cheng, Yanke Chen, Pu Zhao, Na Li, Jianwen Lu, Jianhui Li, Zhengwen Liu, Yi Lv, and Chen Huang, “Dysregulation of miR-638 in hepatocellular carcinoma and its clinical significance,” Oncology Letters, vol. 13, no. 5, pp. 3859–3865, 2017. View at Publisher · View at Google Scholar
  • Junfei Xu, Feiran Wang, Quhui Wang, Lirong Zhu, Yasu Jiang, and Zhixian He, “miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin,” Oncology Letters, vol. 13, no. 3, pp. 1319–1324, 2017. View at Publisher · View at Google Scholar
  • Mark J. Millan, “Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: an integrative review,” Progress in Neurobiology, 2017. View at Publisher · View at Google Scholar
  • Yichao Mo, Xueru Li, Siyao Che, Qinshou Chen, Yaoyong Lu, Peng Wang, Simin Huang, Longguang He, Dasheng Li, Fuliang Li, Junwei Huang, and Xiaoxia Lin, “Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma,” Tumor Biology, vol. 39, no. 2, 2017. View at Publisher · View at Google Scholar
  • Lucía Pastro, Pablo Smircich, Andrés Di Paolo, Lorena Becco, María A. Duhagon, José Sotelo-Silveira, and Beatriz Garat, “Nuclear Compartmentalization Contributes to Stage-Specific Gene Expression Control in Trypanosoma cruzi,” Frontiers in Cell and Developmental Biology, vol. 5, 2017. View at Publisher · View at Google Scholar
  • Ye Jin, Xiuge Gu, Mengying Li, Dongxu Liu, and Fulan Wei, “Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation,” BMC Genetics, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Wenkang Luan, Liang Liu, Xin Ni, Feng Lu, Bin Xu, Rubo Li, Yan Shi, Yun Xia, and Jinlong Wang, “Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p,” Oncotarget, vol. 8, no. 49, pp. 85401–85414, 2017. View at Publisher · View at Google Scholar
  • Ming Zhu, Min Zhang, Lijuan Xing, Wenzong Li, Haiyang Jiang, Lei Wang, and Miaoyun Xu, “Transcriptomic Analysis of Long Non-Coding RNAs and Coding Genes Uncovers a Complex Regulatory Network That Is Involved in Maize Seed Development,” Genes, vol. 8, no. 10, pp. 274, 2017. View at Publisher · View at Google Scholar
  • Xiaohui Zhao, Yimin Liu, Zhihua Li, Shangyou Zheng, Zairui Wang, Wenzhu Li, Zhuofei Bi, Liting Li, Yanhui Jiang, Yuming Luo, Qing Lin, Zhiqiang Fu, and Chen Rufu, “Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa-miR-29b-3p in pancreatic ductal adenocarcinoma,” Journal of Cellular and Molecular Medicine, 2017. View at Publisher · View at Google Scholar
  • Simin Li, Xiujie Chen, Xiangqiong Liu, Yang Yu, Hongying Pan, Rainer Haak, Jana Schmidt, Dirk Ziebolz, and Gerhard Schmalz, “Complex integrated analysis of lncRNAs-miRNAs-mRNAs in oral squamous cell carcinoma,” Oral Oncology, vol. 73, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Jia Yao, Feng Xu, Danhua Zhang, Wenjun Yi, Xianyu Chen, Gannong Chen, and Enxiang Zhou, “TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Yu-Ze Song, and Ji-Feng Li, “Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p,” Tumor Biology, vol. 39, no. 7, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  • Liyun Fu, Junming Guo, Qingqing Chen, Ting Yao, Tianwen Li, Sheng Ying, and Yaoren Hu, “Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma,” Oncotarget, vol. 8, no. 27, pp. 43878–43888, 2017. View at Publisher · View at Google Scholar
  • Hang Yu, and Long Rong, “Emerging role of long non-coding RNA in the development of gastric cancer,” World Journal of Gastrointestinal Oncology, vol. 10, no. 9, pp. 260–270, 2018. View at Publisher · View at Google Scholar
  • Xuejiao Yin, Sui Huang, Ruiqi Zhu, Fengjuan Fan, Chunyan Sun, and Yu Hu, “Identification of long non-coding RNA competing interactions and biological pathways associated with prognosis in pediatric and adolescent cytogenetically normal acute myeloid leukemia,” Cancer Cell International, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Yehong Li, and Zhongwen Yang, “Analysis of competing endogenous RNA network to identify the key RNAs associated with prostate adenocarcinoma,” Pathology - Research and Practice, 2018. View at Publisher · View at Google Scholar
  • Lei Li, Guohua Lv, Bing Wang, and Lei Kuang, “The role of lncRNA XIST/miR-211 axis in modulating the proliferation and apoptosis of osteoarthritis chondrocytes through CXCR4 and MAPK signaling,” Biochemical and Biophysical Research Communications, 2018. View at Publisher · View at Google Scholar
  • Gabriela O. Bodea, Eleanor G. Z. McKelvey, and Geoffrey J. Faulkner, “Retrotransposon-induced mosaicism in the neural genome,” Open Biology, vol. 8, no. 7, pp. 180074, 2018. View at Publisher · View at Google Scholar
  • Rong Zhang, Hekun Jin, and Fan Lou, “The Long Non-Coding RNA TP73-AS1 Interacted With miR-142 to Modulate Brain Glioma Growth Through HMGB1/RAGE Pathway,” Journal of Cellular Biochemistry, vol. 119, no. 4, pp. 3007–3016, 2018. View at Publisher · View at Google Scholar
  • Shuchen Li, Chujiao Lin, Jie Zhang, Huangheng Tao, Huan Liu, Guohua Yuan, and Zhi Chen, “Quaking promotes the odontoblastic differentiation of human dental pulp stem cells,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Wojciech Rosikiewicz, Magdalena Regina Kubiak, Elżbieta Wanowska, Izabela Makałowska, and Michał Wojciech Szcześniak, “Natural antisense transcripts in diseases: From modes of action to targeted therapies,” Wiley Interdisciplinary Reviews: RNA, vol. 9, no. 2, 2018. View at Publisher · View at Google Scholar
  • Weijiang Zhang, Jing Fei, Shuqian Yu, Jiayu Shen, Xiaoqing Zhu, Annapurna Sadhukhan, Weiguo Lu, and Jianwei Zhou, “LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Shuai Xiao, Rensheng Wang, Xiangwei Wu, Wen Liu, and Shanshan Ma, “ The Long Noncoding RNA TP73-AS1 Interacted with miR-124 to Modulate Glioma Growth by Targeting Inhibitor of Apoptosis-Stimulating Protein of p53 ,” DNA and Cell Biology, vol. 37, no. 2, pp. 117–125, 2018. View at Publisher · View at Google Scholar
  • Aihong Wang, Canhui Jin, Hongyu Li, Qiaohong Qin, and Lei Li, “LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p/FOXF2 signaling pathway,” International Journal of Biological Macromolecules, vol. 120, pp. 1705–1713, 2018. View at Publisher · View at Google Scholar
  • Yinan Chen, Fengbo Zhao, Daming Cui, Rui Jiang, Jian Chen, Qingfeng Huang, and Jinlong Shi, “HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8,” International Journal of Cancer, 2018. View at Publisher · View at Google Scholar
  • Guotian Yin, Xiuli Yang, Qiong Li, and Zhikun Guo, “GATA1 activated lncRNA (Galont) promotes anoxia/reoxygenation-induced autophagy and cell death in cardiomyocytes by sponging miR-338,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Chen Chen, Tao Jiang, Fei Song, Xingjia Shen, Ping Qian, and Xin Wang, “bmo-miR-275 down-regulates expression of Bombyx mori sericin gene 2 in vitro,” PLoS ONE, vol. 13, no. 1, 2018. View at Publisher · View at Google Scholar
  • Liting Yang, Xiaoling Li, Guiyuan Li, Wei Xiong, Fang Xiong, Shanshan Zhang, Can Guo, Ni Xie, Yong Li, Zhaoyang Zeng, Yanyan Tang, Yi He, Fang Wei, Bo Xiang, and Ming Zhou, “LncRNAs regulate cancer metastasis via binding to functional proteins,” Oncotarget, vol. 9, no. 1, pp. 1426–1443, 2018. View at Publisher · View at Google Scholar